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SCH-442416

SIGMA/S6451 - ≥98% (HPLC)

Synonym: 2-(2-Furanyl)-7-[3-(4-methoxyphenyl)propyl]-7H-pyrazolo [4,3-e][1,2,4]triazolo[1,5-c]pyrimidin-5-amine; 5-amino-7-(3-(4-methoxyphenyl)propyl)-2-(2 furyl)pyrazolo[4,3-e]-1,2,4-triazolo[1,5-c]pyrimidine; 5-Amino-7-[3-(4-methoxy)phenylpropyl]-2-(2-furyl)-pyrazolo[4,3-e]-1,2,4-triazolo[1,5-c]pyrimidine

CAS Number: 316173-57-6
Empirical Formula (Hill Notation): C20H19N7O2
Molecular Weight: 389.41
MDL Number: MFCD08703126
Linear Formula: C20H19N7O2
Product Type: Chemical
Catalog Number PKG Qty. Price Quantity
45-S6451-5MG 5 mg
 $112.00
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45-S6451-25MG 25 mg
 $445.00
1/EA		 Add To Favorites

 

assay ≥98% (HPLC)
color light tan to tan
form powder
InChI 1S/C20H19N7O2/c1-28-14-8-6-13(7-9-14)4-2-10-26-18-15(12-22-26)19-23-17(16-5-3-11-29-16)25-27(19)20(21)24-18/h3,5-9,11-12H,2,4,10H2,1H3,(H2,21,24)
InChI key AEULVFLPCJOBCE-UHFFFAOYSA-N
Quality Level 100 
SMILES string COc1ccc(CCCn2ncc3c2nc(N)n4nc(nc34)-c5ccco5)cc1
solubility DMSO: ≥20 mg/mL
storage condition desiccated
storage temp. 2-8°C
Application: SCH-442416 has been used:
• as a selective adenosine A2A antagonist to study its effects on cyclic adenosine monophosphate (cAMP) production in T/C-28a2 chondrocytes or hFOB 1.19 osteoblasts 
• as a presynaptic A2A receptor antagonists to study its effects on receptor blockade on δ9-Tetrahydrocannabinol (THC) self-administration in squirrel monkeys
• as a presynaptic A2A receptor antagonists to study its effects on cocaine-induced locomotion and cocaine-seeking in mice

Biochem/physiol Actions: SCH-442416 potent and selective Adenosine A2a antagonist. SCH-442416 is >10,000-fold selective for A2a compared to other adensosine receptors.
Features and Benefits: This compound is featured on the Adenosine Receptors  page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here .
Packaging: 5, 25 mg in glass bottle
RIDADR NONH for all modes of transport
WGK Germany WGK 3
Flash Point(F) Not applicable
Flash Point(C) Not applicable
Purity ≥98% (HPLC)
Storage Temp. 2-8°C
UNSPSC 12352200

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