Sodium orthovanadate
SIGMA/S6508 - ≥90% (titration)
Synonym: Trisodium vanadate
CAS Number: 13721-39-6
Empirical Formula (Hill Notation): Na3O4V
Molecular Weight: 183.91
EC Number: 237-287-9
MDL Number: MFCD00003511
Linear Formula: Na3VO4
Product Type: Chemical
This picture is provided solely for illustration purposes. Optical properties of the actual product may deviate. Relevant product information is printed on labeled products and other accompanying or available information material. This image depicts SKU: S6508-50G
This picture is provided solely for illustration purposes. Optical properties of the actual product may deviate. Relevant product information is printed on labeled products and other accompanying or available information material. This image depicts SKU: S6508-250G
This picture is provided solely for illustration purposes. Optical properties of the actual product may deviate. Relevant product information is printed on labeled products and other accompanying or available information material. This image depicts SKU: S6508-10G
| assay | ≥90% (titration) |
| biological source | synthetic (organic) |
| color | white to off-white |
| form | crystalline powder |
| InChI | 1S/3Na.4O.V/q3*+1;;3*-1; |
| InChI key | IHIXIJGXTJIKRB-UHFFFAOYSA |
| mp | 850-866 °C (lit.) |
| Quality Level | 200  |
| reaction suitability | reagent type: catalyst core: vanadium |
| SMILES string | [Na+].[Na+].[Na+].[O-][V] |
| solubility | H2O: soluble |
| Application: | Sodium orthovandate was used to prepare the stop solution in dephosphorylation assay of insulin receptor kinase.26 It was one of the reagents used in the development of Matrix ChIP that utilizes surface-immobilized antibodies.27 |
| Biochem/physiol Actions: | Inhibits ATPase, alkaline phosphatase and tyrosine phosphatase. Decavanadate, which is formed at acidic pH, inhibits inositol 1,4,5-trisphosphate (IP3)-induced Ca2+ release from endocrine cells and blocks IP3 binding to its receptor in brain tissue. |
| Biochem/physiol Actions: | Sodium orthovandate suppresses the activation of p53-mediated apoptosis triggered in response to radiation. It reduces the detrimental effects of hematopoietic syndrome, hematopoiesis and delayed genotoxic effects of induced by total body irradiation of mice.24 In combination with menadione, orthovandate prevents the migration of detached human glioma cells in response to anti-cancer drugs.25 |
| Features and Benefits: | This compound is a featured product for Kinase Phosphatase Biology research. Click here to discover more featured Kinase Phosphatase Biology products. Learn more about bioactive small molecules for other areas of research at sigma.com/discover-bsm . |
| Features and Benefits: | This compound is featured on the Phosphoprotein Phosphatases (Tyrosine) page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here . |
| Other Notes: | 2024 CiteAb Award Winner for Supplier Succeeding in Parkinson′s Research  |
| Packaging: | 10, 50, 250 g in poly bottle |
| Symbol |  GHS07 |
| Signal word | Warning |
| Hazard statements | H302 |
| Precautionary statements | P301 + P312 + P330 |
| Hazard Codes | Xn |
| Risk Statements | 20/21/22 |
| Safety Statements | 22-36 |
| RIDADR | NONH for all modes of transport |
| WGK Germany | WGK 3 |
| Flash Point(F) | Not applicable |
| Flash Point(C) | Not applicable |
| Purity | ≥90% (titration) |
| mp | 850-866 °C (lit.) |
| UNSPSC | 12352200 |