N-Succinyl-Leu-Leu-Val-Tyr-7-Amido-4-Methylcoumarin

SIGMA/S6510 - ≥90% (HPLC)

CAS Number: 94367-21-2
Empirical Formula (Hill Notation): C₄₀H₅₃N₅O₁₀
Molecular Weight: 763.88
MDL Number: MFCD00080248
Linear Formula: C₄₀H₅₃N₅O₁₀
Product Type: Chemical

Catalog Number	PKG Qty.	Price	Quantity


45-S6510-1MG	1 mg	$72.40 1/EA		Add To Favorites
45-S6510-5MG	5 mg	$205.00 1/EA		Add To Favorites
45-S6510-10MG	10 mg	$362.00 1/EA		Add To Favorites

Properties
Descriptions
Safety Info.
Basic Data

assay	≥90% (HPLC)
form	powder
InChI	1S/C40H53N5O10/c1-21(2)16-29(42-33(47)14-15-34(48)49)38(52)43-30(17-22(3)4)39(53)45-36(23(5)6)40(54)44-31(19-25-8-11-27(46)12-9-25)37(51)41-26-10-13-28-24(7)18-35(50)55-32(28)20-26/h8-13,18,20-23,29-31,36,46H,14-17,19H2,1-7H3,(H,41,51)(H,42,47)(H,43,52)(H,44,54)(H,45,53)(H,48,49)
InChI key	UVFAEQZFLBGVRM-UHFFFAOYSA-N
Quality Level	200
SMILES string	CC(C)CC(NC(=O)CCC(O)=O)C(=O)NC(CC(C)C)C(=O)NC(C(C)C)C(=O)NC(Cc1ccc(O)cc1)C(=O)Nc2ccc3C(C)=CC(=O)Oc3c2
solubility	0.1% trifluoroacetic acid in acetonitrile: water (3:1): 1 mg/mL, clear, colorless
storage temp.	−20°C

Amino Acid Sequence:	N-Suc-Leu-Leu-Val-Tyr-7-AMC
Application:	N-succinyl-Leu-Leu-Val-Tyr-7-amido-4-methylcoumarin was used in proteasome chymotrypsin-like activity assay in Jurkat cell lysate⁶ and crude cell lysate of rice.⁷
Biochem/physiol Actions:	In the presence of chymotrypsin-like enzyme activity, the fluorophore, 7-amido-4-methylcoumarin is released from N-succinyl-Leu-Leu-Val-Tyr-7-amido-4-methylcoumarin. The fluorescence obtained is a measure of the enzyme activity.⁶
General description:	Fluorogenic substrate for chymotrypsin-like enzymes, such as cathepsin B and calpain which have been implicated in programmed cell death.
Packaging:	Bottomless glass bottle. Contents are inside inserted fused cone.

Hazard statements	H413
Precautionary statements	P273
RIDADR	NONH for all modes of transport
WGK Germany	WGK 3

Purity	≥90% (HPLC)
Storage Temp.	−20°C
UNSPSC	12352200

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