Anti-Sodium Channel, Pan antibody produced in rabbit
SIGMA/S6936 - affinity isolated antibody, lyophilized powder
Synonym: Anti-SP19
MDL Number: MFCD02097413
Product Type: Chemical
Immunohistochemistry-immunofluorescence JOURNAL CITATION: Improved Methods for Fluorescence Microscopy Detection of Macromolecules at the Axon Initial Segment. By: Alshammari, M. A., Alshammari, T. K., et al. in Front Cell Neurosci, 2016. PubMed ID: 26909021 Image collected and cropped by CiteAb from the following publication, (http://journal.frontiersin.org/Article/10.3389/fncel.2016.00005/abstract), provided under a CC-BY license. Image might reflect a new usage that is not reflected in claims on product description or independently verified by Merck KGaA, Darmstadt, Germany. For Research Use Only. Not for use in diagnostic procedures.
Immunohistochemistry Anti-Pan Nav: Cat. No. S6936: Immunohistochemical staining of Rat cerebellum using Anti-Pan Nav antibody. A. Nav channels (red) appear in Purkinje cell bodies (vertical arrows) and in cells of the molecular layer (Mol), (horizontal arrows). B. Staining of Parvalbumin (green) in the same brain section. C. Confocal merge of Nav channels and Parvalbumin demonstrates the location of Nav channels to the cell body of Purkinje neurons.
Immunoblotting Anti-Pan NaV: Cat. No. S6936: Western blot analysis of Rat brain membranes. Lanes 1. Anti-Pan NaV antibody, (1:200). 2. Anti-Pan NaV antibody, preincubated with the control peptide antigen.
| antibody form | affinity isolated antibody |
| antibody product type | primary antibodies |
| biological source | rabbit |
| clone | polyclonal |
| conjugate | unconjugated |
| form | lyophilized powder |
| Quality Level | 100  |
| species reactivity | rat |
| storage temp. | −20°C |
| target post-translational modification | unmodified |
| technique(s) | immunohistochemistry (formalin-fixed, paraffin-embedded sections): suitable |
| immunoprecipitation (IP): suitable | |
| western blot (chemiluminescent): 1:200-1:600 | |
| UniProt accession no. | P04774  |
| Application: | Anti-Sodium Channel, Pan antibody is suitable for use in immunohistochemistry (formalin-fixed, paraffin-embedded sections), immunoprecipitation and chemiluminescent western blot. |
| Application: | Applications in which this antibody has been used successfully, and the associated peer-reviewed papers, are given below. Immunofluorescence (1 paper) Immunohistochemistry (1 paper) |
| Disclaimer: | Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals. |
| General description: | Voltage-gated sodium channels (VGSC) are membrane proteins that are usually present in excitable cells. These sodium channels regulate neurological functions such as the generation of action potentials in nerve cells. Alterations in neurological sodium ion channels have been associated with epilepsy, whereas mutations in cardiac sodium channels have been linked to long QT syndrome . Anti-Sodium Channel, Pan antibody is specific for the α subunit of VGSC in rats. |
| Immunogen: | synthetic peptide corresponding to amino acids 1491-1508 of the α subunit of rat type I voltage-gated sodium channel (VGSC, SP19) (with additional C-terminal cysteine). The epitope corresponds to the sequence in the intracellular loop between the III and IV domains of the VGSC α subunit.This epitope is identical in vertebrates, and highly homologous in mollusks and insects. |
| Physical form: | Lyophilized from phosphate buffered saline, pH 7.4, containing 1% bovine serum albumin, and 0.05% sodium azide. |
| Symbol |  GHS06 |
| Signal word | Danger |
| Hazard statements | H302 + H332 - H311 - H412 |
| Precautionary statements | P273 - P280 - P301 + P312 + P330 - P302 + P352 + P312 - P304 + P340 + P312 |
| Hazard Codes | T |
| Risk Statements | 24/25-52/53 |
| Safety Statements | 36/37-45-61 |
| RIDADR | UN 2811 6.1 / PGIII |
| WGK Germany | WGK 3 |
| Flash Point(F) | Not applicable |
| Flash Point(C) | Not applicable |
| Storage Temp. | −20°C |
| UNSPSC | 12352203 |