Surfen hydrate
SIGMA/S6951 - ≥98% (HPLC)
Synonym: (bis-
CAS Number: 1241801-02-4
Empirical Formula (Hill Notation): C21H20N6O · xH2O
Molecular Weight: 372.42 (anhydrous basis)
MDL Number: MFCD17215963
Linear Formula: C21H20N6O · xH2O
Product Type: Chemical
| assay | ≥98% (HPLC) |
| color | white to beige |
| form | powder |
| InChI | 1S/C21H20N6O.H2O/c1-11-7- |
| InChI key | UXYZYUHSZVKWTR-UHFFFAOYSA |
| Quality Level | 100  |
| SMILES string | O.Cc1cc(N)c2cc(NC(=O)Nc3c |
| solubility | DMSO: 2 mg/mL, clear |
| storage temp. | 2-8°C |
| Application: | Surfen hydrate may be used as an antagonist to heparin. Surfen hydrate has been used in the inhibition of multiple voltage-gated calcium channels in human embryonic kidney cells. |
| Biochem/physiol Actions: | Surfen is a heparan sulfate antagonist, originally developed in the late thirties as an excipient for the production of depot insulin. Heparan sulfate (HS) is structurally related to heparin but contains fewer sulfate groups per disaccharide, and it exists almost exclusively attached to protein cores of proteoglycans, which cells either display on the plasma membrane or secrete into the extracellular matrix. Surfen binds to the chains of glycosaminoglycan (GAG)/HS and prevents binding of the enzymes and proteins thus act as HS antagonist. Surfen is more potent than protamine, a clinically used heparin antagonist. |
| Biochem/physiol Actions: | Surfen is a heparan sulfate antagonist. |
| Packaging: | 5, 25 mg in glass bottle |
| Hazard statements | H413 |
| RIDADR | NONH for all modes of transport |
| WGK Germany | WGK 3 |
| Flash Point(F) | Not applicable |
| Flash Point(C) | Not applicable |
| Purity | ≥98% (HPLC) |
| Storage Temp. | 2-8°C |
| UNSPSC | 12352200 |