SD-208

SIGMA/S7071 - ≥98% (HPLC), powder

Synonym: 2-(5-Chloro-2-fluorophenyl)pteridin-4-yl]pyridin-4-yl-amine

CAS Number: 627536-09-8
Empirical Formula (Hill Notation): C₁₇H₁₀ClFN₆
Molecular Weight: 352.75
MDL Number: MFCD11519969
Linear Formula: C₁₇H₁₀ClFN₆
Product Type: Chemical

Catalog Number	PKG Qty.	Price	Quantity


45-S7071-5MG	5 mg	$244.00 1/EA		Add To Favorites
45-S7071-25MG	25 mg	$845.00 1/EA		Add To Favorites

Properties
Descriptions
Safety Info.
Basic Data

assay	≥98% (HPLC)
color	off-white to tan
form	powder
InChI	1S/C17H10ClFN6/c18-10-1-2-13(19)12(9-10)15-24-16-14(21-7-8-22-16)17(25-15)23-11-3-5-20-6-4-11/h1-9H,(H,20,22,23,24,25)
InChI key	BERLXWPRSBJFHO-UHFFFAOYSA-N
Quality Level	100
SMILES string	Fc1ccc(Cl)cc1-c2nc(Nc3ccncc3)c4nccnc4n2
solubility	DMSO: >5 mg/mL
storage temp.	2-8°C

Application:	SD-208 was used to inhibit the activity of ALK5 kinase in bovine retinal vascular cells.²
Biochem/physiol Actions:	SD-208 is a novel transforming growth factor beta receptor I (TGF-βR I) kinase inhibitor. SD-208 inhibits growth and invasiveness and enhances immunogenicity of murine and human glioma cells in vitro and in vivo.
Biochem/physiol Actions:	SD-208 is an inhibitor of TGF β receptor 1 kinase that is reportedly effective against human malignant gliomas. It increases the lytic activity and tumor infiltration by polyclonal natural killer cells, CD8 T cells and macrophages.¹
Biochem/physiol Actions:	SD-208 is TGF-βR I kinase inhibitor with IC₅₀ =49 nM based on direct enzymatic assay of TGFRI kinase (ALK5) activity with a specificity of >100-fold against TGFRII and at least 17-fold over members of a panel of related protein kinases including p38a, p38b, p38d, JNK1, EGFR, MAPKAPK2, MKK6, ERK2, PKC, PKA, PKD, CDC2, and CaMKII.
Packaging:	5, 25 mg in glass bottle

Symbol	GHS07
Signal word	Warning
Hazard statements	H302
Hazard Codes	Xn
Risk Statements	22
RIDADR	NONH for all modes of transport
WGK Germany	WGK 3
Flash Point(F)	Not applicable
Flash Point(C)	Not applicable

Purity	≥98% (HPLC)
Storage Temp.	2-8°C
UNSPSC	12352200

Choose a favorite list for this item:

Catalog Number	Description	Price

		$

Please choose a list :

Continue Shopping

Returns/Order support

Please fill out the form below if you want to request order support from Krackeler Scientific.