Synonym: EI 546 sodium salt hydrate; Elaspol sodium salt hydrate; LY 544349 sodium salt hydrate; Ono-5046 sodium salt hydrate; o-(p-Hydroxybenzenesulfonamido)hippuric acid, pivalate (ester) sodium salt hydrate
CAS Number: 127373-66-4 (free acid)
Empirical Formula (Hill Notation): C20H22N2O7S · xNa+ · yH2O
Molecular Weight: 434.46 (anhydrous free acid basis)
Linear Formula: C20H22N2O7S · xNa+ · yH2O
Product Type: Chemical
| assay |
≥98% (HPLC) |
| color |
white to off-white |
| form |
solid |
| InChI |
1S/C20H22N2O7S/c1-20(2,3)19(26)29-13-8-10-14(11-9-13)30(27,28)22-16-7-5-4-6-15(16)18(25)21-12-17(23)24/h4-11,22H,12H2,1-3H3,(H,21,25)(H,23,24) |
| InChI key |
BTGNGJJLZOIYID-UHFFFAOYSA-N |
| Quality Level |
100  |
| SMILES string |
[S](=O)(=O)(Nc2c(cccc2)C(=O)NCC(=O)O)c1ccc(cc1)OC(=O)C(C)(C)C |
| solubility |
DMSO: 10 mg/mL, clear |
| storage temp. |
room temp |
| Application: |
Sivelestat sodium salt hydrate may be used to inhibit human neutrophil elastase-mediated cell signaling. |
| Biochem/physiol Actions: |
Sivelestat is a competitive human neutrophil elastase (HNE) inhibitor (IC50 = 44 nM, Ki = 0.2 μM). It also inhibits leukocyte elastase obtained from rabbit, rat, hamster and mouse (IC50 = 19 to 49 nM). However, it does not inhibit trypsin, thrombin, plasmin, plasma kallikrein, pancreas kallikrein, chymotrypsin and cathepsin G even at 100 μM. In in-vivo studies, it suppressed lung hemorrhage in hamster (ID50 = 82 μg/kg) by intratracheal administration and increase of skin capillary permeability in guinea pig (ID50 = 9.6 mg/kg) by intravenous administration, both of which were induced by human neutrophil elastase. |
| Biochem/physiol Actions: |
Sivelestat is a competitive human neutrophil elastase (HNE) inhibitor. |
| Packaging: |
5, 25 mg in glass bottle |
| RIDADR |
NONH for all modes of transport |
| WGK Germany |
nwg |
| Flash Point(F) |
Not applicable |
| Flash Point(C) |
Not applicable |
| Purity |
≥98% (HPLC) |
| Storage Temp. |
room temp |
| UNSPSC |
12352200 |
