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Sivelestat sodium salt hydrate

SIGMA/S7198 - ≥98% (HPLC), solid

Synonym: EI 546 sodium salt hydrate; Elaspol sodium salt hydrate; LY 544349 sodium salt hydrate; Ono-5046 sodium salt hydrate; o-(p-Hydroxybenzenesulfonamido)hippuric acid, pivalate (ester) sodium salt hydrate

CAS Number: 127373-66-4 (free acid)
Empirical Formula (Hill Notation): C20H22N2O7S · xNa+ · yH2O
Molecular Weight: 434.46 (anhydrous free acid basis)
Linear Formula: C20H22N2O7S · xNa+ · yH2O
Product Type: Chemical
Catalog Number PKG Qty. Price Quantity
45-S7198-5MG 5 mg
 $119.00
1/EA		 Add To Favorites
45-S7198-25MG 25 mg
 $491.00
1/EA		 Add To Favorites
This picture is provided solely for illustration purposes, it may have been created or edited with AI. Optical properties of the actual product may deviate. Relevant product information is printed on labeled products and other accompanying or available information material.
This image depicts S7198-5MG.

 

assay ≥98% (HPLC)
color white to off-white
form solid
InChI 1S/C20H22N2O7S/c1-20(2,3)19(26)29-13-8-10-14(11-9-13)30(27,28)22-16-7-5-4-6-15(16)18(25)21-12-17(23)24/h4-11,22H,12H2,1-3H3,(H,21,25)(H,23,24)
InChI key BTGNGJJLZOIYID-UHFFFAOYSA-N
Quality Level 100 
SMILES string [S](=O)(=O)(Nc2c(cccc2)C(=O)NCC(=O)O)c1ccc(cc1)OC(=O)C(C)(C)C
solubility DMSO: 10 mg/mL, clear
storage temp. room temp
Application: Sivelestat sodium salt hydrate may be used to inhibit human neutrophil elastase-mediated cell signaling.
Biochem/physiol Actions: Sivelestat is a competitive human neutrophil elastase (HNE) inhibitor (IC50 = 44 nM, Ki = 0.2 μM). It also inhibits leukocyte elastase obtained from rabbit, rat, hamster and mouse (IC50 = 19 to 49 nM). However, it does not inhibit trypsin, thrombin, plasmin, plasma kallikrein, pancreas kallikrein, chymotrypsin and cathepsin G even at 100 μM. In in-vivo studies, it suppressed lung hemorrhage in hamster (ID50 = 82 μg/kg) by intratracheal administration and increase of skin capillary permeability in guinea pig (ID50 = 9.6 mg/kg) by intravenous administration, both of which were induced by human neutrophil elastase.
Biochem/physiol Actions: Sivelestat is a competitive human neutrophil elastase (HNE) inhibitor.
Packaging: 5, 25 mg in glass bottle
RIDADR NONH for all modes of transport
WGK Germany nwg
Flash Point(F) Not applicable
Flash Point(C) Not applicable
Purity ≥98% (HPLC)
Storage Temp. room temp
UNSPSC 12352200

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