Scriptaid
SIGMA/S7817 - ≥95%, solid
Synonym: 6-(1,3-Dioxo-1H, 3H-
CAS Number: 287383-59-9
Empirical Formula (Hill Notation): C18H18N2O4
Molecular Weight: 326.35
MDL Number: MFCD00386477
Linear Formula: C18H18N2O4
Product Type: Chemical
| assay | ≥95% |
| biological source | synthetic (organic) |
| form | solid |
| InChI | 1S/C18H18N2O4/c21-15(19-2 |
| InChI key | JTDYUFSDZATMKU-UHFFFAOYSA |
| mp | 160-161 °C |
| Quality Level | 100  |
| SMILES string | ONC(=O)CCCCCN1C(=O)c2cccc |
| solubility | DMSO: 1 mg/mL |
| DMSO:methanol (1:1): complete 2 mg/ml, clear, colorless to faintly yellow | |
| methanol: soluble | |
| storage temp. | −20°C |
| Application: | Scriptaid has been used in post activation of oocytes and embryo culture. |
| Application: | Scriptaid was used to enhance transcriptional activity in cloning procedures by somatic cell nuclear transfer.5,6 |
| Biochem/physiol Actions: | Histone deacetylase inhibitor with lower toxicity than trichostatin A. |
| Biochem/physiol Actions: | Histone deacetylase inhibitor with lower toxicity than trichostatin A; used to enhance protein expression. |
| Biochem/physiol Actions: | Scriptaid inhibits the cell cycle progression of ovarian cancer cells by inducing arrest in G0/G1 and/or G2/M phase. Treatment of cells with scriptaid results in loss of mitochondrial membrane potential and increased acetylation of H3 and H4 histone tails.2 Sciptaid induces expression of γ-globin in human erythroid progenitors via p38 signaling and may be a treatment option for sickle cell disease.3 It enhances the transcriptional activity and protein expression in mouse embryos. This is useful in producing cloned, inbred mouse embryos that develop normally into adulthood with regular reproductive ability.4 |
| Features and Benefits: | This compound is a featured product for Gene Regulation research. Click here to discover more featured Gene Regulation products. Learn more about bioactive small molecules for other areas of research at sigma.com/discover-bsm . |
| General description: | Scriptaid is a histone deacetylase (HDAC) inhibitor, which enhances global acetylation of histones. It improves transcriptional activity and protein expression. Scriptaid inhibits tumor growth. It decreases telomerase activity and stimulates glioma cell apoptosis. |
| Legal Information: | Sold under license of U.S. Patent No. 6,544,957. |
| Packaging: | 1 mg in poly bottle |
| Packaging: | 5 mg in glass bottle |
| RIDADR | NONH for all modes of transport |
| WGK Germany | WGK 3 |
| Flash Point(F) | Not applicable |
| Flash Point(C) | Not applicable |
| Purity | ≥95% |
| mp | 160-161 °C |
| Storage Temp. | −20°C |
| UNSPSC | 12352203 |