Synonym: 9H-Indeno-[1,2-e]-[1,2,5]-oxadiazolo-[3,4-b]-pyrazin-9-one
CAS Number: 67200-34-4
Empirical Formula (Hill Notation): C11H4N4O2
Molecular Weight: 224.18
MDL Number: MFCD00451458
Linear Formula: C11H4N4O2
Product Type: Chemical
| assay |
≥98% (HPLC) |
| color |
yellow |
| form |
powder |
| InChI |
1S/C11H4N4O2/c16-9-6-4-2-1-3-5(6)7-8(9)13-11-10(12-7)14-17-15-11/h1-4H |
| InChI key |
SFSSAKVWCKFRHE-UHFFFAOYSA-N |
| Quality Level |
100  |
| SMILES string |
O=C1c2ccccc2-c3nc4nonc4nc13 |
| solubility |
DMSO: ≥30 mg/mL |
| storage temp. |
2-8°C |
| Application: |
SMER3 may be used in cell signaling studies. |
| Biochem/physiol Actions: |
Inhibition of SCFMet30 by SMER3 blocks the ubiquitination of Met4 and activates the Met4-containing transcription complex. The induction of MET-genes results in cell cycle arrest and reduced cell proliferation.1 |
| Biochem/physiol Actions: |
Small molecule enhancer of rapamycin (SMER); specific inhibitor of Ubiquitin E3 ligase. |
| Packaging: |
5, 25 mg in glass bottle |
| Hazard Codes |
Xn |
| Risk Statements |
22 |
| RIDADR |
NONH for all modes of transport |
| WGK Germany |
WGK 1 |
| Flash Point(F) |
Not applicable |
| Flash Point(C) |
Not applicable |
| Purity |
≥98% (HPLC) |
| Storage Temp. |
2-8°C |
| UNSPSC |
12352200 |
