Synonym: 4-Amino-7-hydroxy-2-methyl-5,6,7,8-tetrahydrobenzo[b]thieno[2,3-b]pyridine-3-carboxylic acid but-2-ynyl ester
CAS Number: 160296-13-9
Empirical Formula (Hill Notation): C17H18N2O3S
Molecular Weight: 330.40
MDL Number: MFCD00918851
Linear Formula: C17H18N2O3S
Product Type: Chemical
| color |
off-white |
| form |
solid |
| InChI |
1S/C17H18N2O3S/c1-3-4-7-22-17(21)13-9(2)19-16-14(15(13)18)11-6-5-10(20)8-12(11)23-16/h10,20H,5-8H2,1-2H3,(H2,18,19) |
| InChI key |
JDTZAGLGBRRCJT-UHFFFAOYSA-N |
| Quality Level |
100  |
| SMILES string |
CC#CCOC(=O)c1c(C)nc2sc3CC(O)CCc3c2c1N |
| solubility |
DMSO: 18 mg/mL |
| |
H2O: insoluble |
| Application: |
SB 205384 was used to study GABA-gated currents in rat locus coeruleus neurons.6 |
| Biochem/physiol Actions: |
GABAA receptor modulator selective for the α3β2γ2 subunit combination. |
| Biochem/physiol Actions: |
SB 205384 is a selective and positive allosteric modulator of non-benzodiazepine site of the GABAA receptor.3 It affects the extrasynaptic GABAA receptors in rat cortical neurons4 and enhances the GABAergic transmission onto pro-opiomelanocortin neurons in mice.5 |
| Legal Information: |
Manufactured and sold under license from GlaxoSmithKline Pharmaceuticals |
| RIDADR |
NONH for all modes of transport |
| WGK Germany |
WGK 3 |
| Flash Point(F) |
Not applicable |
| Flash Point(C) |
Not applicable |
