Synonym: (1S,2R,8R,8aR)-1,2,8-Octahydroindolizidinetriol
CAS Number: 72741-87-8
Empirical Formula (Hill Notation): C8H15NO3
Molecular Weight: 173.21
MDL Number: MFCD00017554
Linear Formula: C8H15NO3
Product Type: Chemical
| antibiotic activity spectrum |
neoplastics |
| assay |
≥98% (TLC) |
| biological source |
Metarrhizium anisopliae |
| color |
white to faint yellow |
| form |
lyophilized powder |
| InChI |
1S/C8H15NO3/c10-5-2-1-3-9-4-6(11)8(12)7(5)9/h5-8,10-12H,1-4H2/t5-,6-,7?,8-/m1/s1 |
| InChI key |
FXUAIOOAOAVCGD-DCDLSZRSSA-N |
| mode of action |
enzyme | inhibits |
| Quality Level |
200  |
| SMILES string |
O[C@@H]1CCCN2C[C@@H](O)[C@@H](O)C12 |
| solubility |
H2O: soluble 1 mg/mL |
| storage condition |
(Keep container tightly closed in a dry and well-ventilated place.) |
| storage temp. |
2-8°C |
| Application: |
Swainsonine is a potent inhibitor of various α-mannosidases, especially of α-mannosidase II. It inhibits glycoprotein processing and also acts as immune modulator. |
| Application: |
Swainsonine is an indolizidine alkaloid from the plant Metarrhizium anisopliae that is used as a potent α-mannosidase inhibitor. Product S8195 has been used in chemical inhibition assays of CHO Lec2 cells to inhibit glycosylation . |
| Biochem/physiol Actions: |
Swainsonine is a potent α-mannosidase inhibitor. It also has antimetastatic, antiproliferative, and immunomodulatory activity . It also inhibits glycoprotein processing. |
| Other Notes: |
Keep container tightly closed in a dry and well-ventilated place. |
| Packaging: |
1MG |
| Preparation Note: |
Soluble in water, methanol, DMSO |
| Hazard Codes |
Xn |
| Risk Statements |
20/21/22 |
| Safety Statements |
36 |
| RIDADR |
NONH for all modes of transport |
| WGK Germany |
WGK 3 |
| Purity |
≥98% (TLC) |
| Storage Temp. |
2-8°C |
| UNSPSC |
51102829 |
