SU 5416
SIGMA/S8442 - ≥98% (HPLC)
Synonym: 1,3-
CAS Number: 204005-46-9
Empirical Formula (Hill Notation): C15H14N2O
Molecular Weight: 238.28
MDL Number: MFCD01940922
Linear Formula: C15H14N2O
Product Type: Chemical
This picture is provided solely for illustration purposes. Optical properties of the actual product may deviate. Relevant product information is printed on labeled products and other accompanying or available information material. This image depicts SKU: S8442-25MG
This picture is provided solely for illustration purposes. Optical properties of the actual product may deviate. Relevant product information is printed on labeled products and other accompanying or available information material. This image depicts SKU: S8442-5MG
| assay | ≥98% (HPLC) |
| color | yellow to yellow-orange |
| form | powder |
| InChI | 1S/C15H14N2O/c1-9-7-10(2) |
| InChI key | WUWDLXZGHZSWQZ-XYOKQWHBSA |
| mp | 221-222 °C |
| Quality Level | 100  |
| SMILES string | Cc1cc(C)c(C=C2C(=O)Nc3ccc |
| solubility | DMSO: 20 mg/mL, clear (warmed) |
| H2O: insoluble | |
| storage temp. | −20°C |
| Application: | SU 5416 has been used to treat HUVEC cells before the tube formation assay to assess its impact on the network generated from tube formation. to induce pulmonary hypertension (PH) in mice to serve as an experimental model |
| Biochem/physiol Actions: | SU 516 inhibits the activity of neuronal nitric oxide synthase and protects the neuronal cells from nitric oxide-mediated neurotoxicity.1 It also acts an agonist of aryl hydrocarbon receptor and is an effective clinical agent for treating autoimmune diseases and transplant rejection.2 |
| Biochem/physiol Actions: | SU 5416 is a vascular endothelial growth factor (VEGF) receptor protein tyrosine kinase 1/2 inhibitor. |
| Features and Benefits: | This compound is a featured product for Kinase Phosphatase Biology research. Click here to discover more featured Kinase Phosphatase Biology products. Learn more about bioactive small molecules for other areas of research at sigma.com/discover-bsm . |
| General description: | SU 5416 is a vascular endothelial growth factor (VEGF) receptor protein tyrosine kinase 1/2 inhibitor. SU 5416 is known to prevent tumor growth and tumor angiogenesis. SU 5416 inhibits the activity of neuronal nitric oxide synthase and protects the neuronal cells from nitric oxide-mediated neurotoxicity. It also acts as an agonist of aryl hydrocarbon receptor and may be an effective clinical agent for treating autoimmune diseases and transplant rejection. |
| Packaging: | 5, 25 mg in glass bottle |
| Hazard Codes | Xi |
| Risk Statements | 36/37/38 |
| Safety Statements | 26-36 |
| RIDADR | NONH for all modes of transport |
| WGK Germany | WGK 3 |
| Flash Point(F) | Not applicable |
| Flash Point(C) | Not applicable |
| Purity | ≥98% (HPLC) |
| mp | 221-222 °C |
| Storage Temp. | −20°C |
| UNSPSC | 51111800 |