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SU 4312

SIGMA/S8567 - ≥98% (HPLC)

Synonym: 3-(4-Dimethylaminobenzylidenyl)-2-indolinone; 3-[[(4-Dimethyl­amino)phenyl]methylene]-1,3-dihydro-2H-indol-2-one, E/Z mixture

CAS Number: 5812-07-7
Empirical Formula (Hill Notation): C17H16N2O
Molecular Weight: 264.32
MDL Number: MFCD00118147
Linear Formula: C17H16N2O
Product Type: Chemical
Catalog Number PKG Qty. Price Quantity
45-S8567-5MG 5 mg
 $156.00
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assay ≥98% (HPLC)
color orange
form powder
InChI 1S/C17H16N2O/c1-19(2)13-9-7-12(8-10-13)11-15-14-5-3-4-6-16(14)18-17(15)20/h3-11H,1-2H3,(H,18,20)/b15-11+
InChI key UAKWLVYMKBWHMX-RVDMUPIBSA-N
Quality Level 100 
SMILES string CN(C)c1ccc(cc1)C=C2C(=O)Nc3ccccc23
solubility DMSO: >10 mg/mL
  H2O: insoluble
storage temp. 2-8°C
Application: SU 4312 was used to study angiogenesis during development of zebrafish embryos.2
Biochem/physiol Actions: SU 4312 inhibits the neuronal NOS and exhibits neuroprotection against NO-mediated neurotoxicity. It might be effective in treatment of neurodegenerative disorders.1
Biochem/physiol Actions: SU 4312 is a vascular endothelial growth factor (VEGF) receptor protein tyrosine kinase 1/2 and platelet derived growth factor (PDGF) receptor inhibitor.
Features and Benefits: This compound is a featured product for Kinase Phosphatase Biology research. Click here  to discover more featured Kinase Phosphatase Biology products. Learn more about bioactive small molecules for other areas of research at sigma.com/discover-bsm .
Other Notes: This product is a mixture of the cis- and trans- isomers. The ratio is about 55:45 based on HPLC.
Packaging: 5 mg in glass bottle
Hazard Codes Xi
Risk Statements 36/37/38
Safety Statements 26-36
RIDADR NONH for all modes of transport
WGK Germany WGK 3
Flash Point(F) Not applicable
Flash Point(C) Not applicable
Purity ≥98% (HPLC)
Storage Temp. 2-8°C
UNSPSC 51111800

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