Fas Ligand, soluble human
SIGMA/S8689 - recombinant, expressed in HEK 293 cells, lyophilized powder
Synonym: SuperFas Ligand™
MDL Number: MFCD01092558
Product Type: Chemical
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| assay | ≥95% (SDS-GE) |
| biological source | human |
| form | lyophilized powder |
| mol wt | 32 kDa by SDS-PAGE (nonglycosylated form, under reducing conditions) |
| 35 kDa by SDS-PAGE (glycosylated form, under reducing conditions) | |
| Quality Level | 200  |
| recombinant | expressed in HEK 293 cells |
| storage temp. | −20°C |
| technique(s) | ligand binding assay: suitable |
| UniProt accession no. | P48023  |
| Application: | ED50 = 1 ng/ml on A20 cells. Does not require any enhancer, as the modified linker sequence already facilitates the formation of active FasL complexes. rhsSuperFas Ligand™ recognizes its receptor Fas (CD95) of the following species: human, rat, mouse. |
| Biochem/physiol Actions: | Fas ligand has also been shown to be involved in the activation of non-apoptotic pathways including proliferation and NF-κ B activation. |
| Biochem/physiol Actions: | Fas ligand, a protein belonging to the tumor necrosis factor (TNF) family of cytokines, induces apoptosis in cells expressing the cell membrane receptor Fas (CD95/Apo-1). |
| Legal Information: | SuperFas Ligand is a trademark of Alexis Biochemicals Corp. |
| RIDADR | NONH for all modes of transport |
| WGK Germany | WGK 3 |
| Flash Point(F) | Not applicable |
| Flash Point(C) | Not applicable |
| Purity | ≥95% (SDS-GE) |
| Storage Temp. | −20°C |
| UNSPSC | 12352202 |