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Sulfaguanidine

SIGMA/S8751

Synonym: 4-Amino-N-(aminoiminomethyl)benzenesulfonamide; 4-Amino-N-guanylbenzenesulfonamide

CAS Number: 57-67-0
Empirical Formula (Hill Notation): C7H10N4O2S
Molecular Weight: 214.24
EC Number: 200-345-9
MDL Number: MFCD00038136
Linear Formula: C7H10N4O2S
Product Type: Chemical
Catalog Number PKG Qty. Price Quantity
45-S8751-25G 25 g
 $62.80
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This picture is provided solely for illustration purposes. Optical properties of the actual product may deviate. Relevant product information is printed on labeled products and other accompanying or available information material.

This image depicts SKU: S8751-100G
This picture is provided solely for illustration purposes. Optical properties of the actual product may deviate. Relevant product information is printed on labeled products and other accompanying or available information material.

This image depicts SKU: S8751-25G
This picture is provided solely for illustration purposes. Optical properties of the actual product may deviate. Relevant product information is printed on labeled products and other accompanying or available information material.

This image depicts SKU: S8751-500G

 

antibiotic activity spectrum Gram-negative bacteria
  Gram-positive bacteria
biological source synthetic (Organic)
color white to off-white
form powder
InChI 1S/C7H10N4O2S/c8-5-1-3-6(4-2-5)14(12,13)11-7(9)10/h1-4H,8H2,(H4,9,10,11)
InChI key BRBKOPJOKNSWSG-UHFFFAOYSA-N
mode of action DNA synthesis | interferes
  enzyme | inhibits
Quality Level 200 
SMILES string NC(=N)NS(=O)(=O)c1ccc(N)cc1
solubility 1 M HCl: soluble 50 mg/mL
Application: Sulfaguanidine is used to block the synthesis of folic acid. It is used to study its effect on microsporidial growth and host cell viability.
Biochem/physiol Actions: Sulfaguanidine is a sulfonamide antibiotic. Sulfonamides block the synthesis of dihydrofolic acid by inhibiting the enzyme dihydropteroate synthase. Sulfonamides are competitive inhibitors of bacterial para-aminobenzoic acid (PABA), which is required for bacterial synthesis of folic acid. Sulfaguanidine is a dihydrofolate reductase (DHFR) inhibitor. Sulfonamides are active against Gram positive bacteria and Gram negative bacteria. Mode of resistance is via the alteration of dihydropteroate synthase or alternative pathway for folic acid synthesis.
General description: Chemical structure: sulfonamide
Other Notes: Keep container tightly closed in a dry and well-ventilated place.Keep in a dry place.Storage class (TRGS 510): Non Combustible Solids
Packaging: 25, 100, 500 g in poly bottle
UNSPSC 51283914

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