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SB-525334

SIGMA/S8822 - ≥98% (HPLC)

Synonym: 6-[2-tert-Butyl-5-(6-methyl-pyridin-2-yl)-1H-imidazol-4-yl]-quinoxaline

CAS Number: 356559-20-1
Empirical Formula (Hill Notation): C21H21N5
Molecular Weight: 343.42
MDL Number: MFCD11045307
Linear Formula: C21H21N5
Product Type: Chemical
Catalog Number PKG Qty. Price Quantity
45-S8822-5MG 5 mg
 $276.00
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45-S8822-25MG 25 mg
 $1040.00
1/EA		 Add To Favorites

 

assay ≥98% (HPLC)
color yellow
form solid
InChI 1S/C21H21N5/c1-13-6-5-7-16(24-13)19-18(25-20(26-19)21(2,3)4)14-8-9-15-17(12-14)23-11-10-22-15/h5-12H,1-4H3,(H,25,26)
InChI key DKPQHFZUICCZHF-UHFFFAOYSA-N
originator GlaxoSmithKline
Quality Level 100 
SMILES string Cc1cccc(n1)-c2[nH]c(nc2-c3ccc4nccnc4c3)C(C)(C)C
solubility DMSO: ≥20 mg/mL
storage temp. 2-8°C
Application: SB-525334 was used to study TGFβ1-mediated human trophoblast differentiation.7
Biochem/physiol Actions: SB-525334 blocks the activation of Smad2/3 induced by TGFβ1 in renal proximal tubule cells.4 The sensitivity of TGFβ1 is decreased by SB-525334 that benefits the pulmonary arterial hypertension condition by reversing the pulmonary arterial pressure.5 SB-525334 is reduces the tumor incidence and size of mesenchymal tumors such as uterine leiomyoma.6
Biochem/physiol Actions: SB-525334 is a potent activin receptor-like kinase (ALK5)/ type I TGFβ-receptor kinase inhibitor with IC50 = 14.3 nM.
Biochem/physiol Actions: SB-525334 is an ALK5/type I TGFβ-R kinase inhibitor.
Features and Benefits: This compound was developed by GlaxoSmithKline . To browse the list of other pharma-developed compounds and Approved Drugs/Drug Candidates, click here .
Packaging: 5, 25 mg in glass bottle
Hazard Codes Xn
Risk Statements 22-36/37/38
Safety Statements 26
RIDADR UN 2811 6.1 / PGIII
WGK Germany WGK 3
Purity ≥98% (HPLC)
Storage Temp. 2-8°C
UNSPSC 12352200

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