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Salermide

SIGMA/S8825 - ≥98% (HPLC)

Synonym: N-{3-[(2-Hydroxy-naphthalen-1-ylmethylene)-amino]-phenyl}-2-phenyl-propionamide

CAS Number: 1105698-15-4
Empirical Formula (Hill Notation): C26H22N2O2
Molecular Weight: 394.47
MDL Number: MFCD12912446
Linear Formula: C26H22N2O2
Product Type: Chemical
Catalog Number PKG Qty. Price Quantity
45-S8825-5MG 5 mg
 $163.00
1/EA		 Add To Favorites
45-S8825-25MG 25 mg
 $659.00
1/EA		 Add To Favorites

 

assay ≥98% (HPLC)
color yellow
form powder
InChI 1S/C26H22N2O2/c1-18(19-8-3-2-4-9-19)26(30)28-22-12-7-11-21(16-22)27-17-24-23-13-6-5-10-20(23)14-15-25(24)29/h2-18,29H,1H3,(H,28,30)/b27-17+
InChI key HQSSEGBEYORUBY-WPWMEQJKSA-N
Quality Level 100 
SMILES string CC(C(=O)Nc1cccc(c1)N=Cc2c(O)ccc3ccccc23)c4ccccc4
solubility DMSO: >10 mg/mL
storage condition desiccated
storage temp. 2-8°C
Application: Salermide was used to treat human pulmonary artery smooth muscle cells to study the effect of SIRT1 inhibition on expression of atrogin by qPCR.1
Biochem/physiol Actions: Salermide is a novel Sirtuin 1 (Sirt1) and Sirtuin 2 (Sirt2) inhibitor (III histone deacetylases inhibitor). In vitro Salermide has a stronger inhibitory effect on Sirt2 than on Sirt1. Salermide induces massive apoptosis in tumor cells. The activity was ascribed to effect of Salermide to the reactivation of proapoptotic genes epigenetically repressed exclusively in cancer cells by Sirt1. Salermide is a stronger Sirtuin inhibitor than sirtinol (Cat. No.S7942).
Biochem/physiol Actions: Salermide is a novel Sirtuin 1 (Sirt1) and Sirtuin 2 (Sirt2) inhibitor. Salermide reactivates proapoptotic genes epigenetically repressed exclusively in cancer cells by Sirt1.
Features and Benefits: This compound is a featured product for Gene Regulation research. Click here  to discover more featured Gene Regulation products. Learn more about bioactive small molecules for other areas of research at sigma.com/discover-bsm .
Packaging: 5, 25 mg in glass bottle
Hazard Codes Xi
Risk Statements 43-52/53
Safety Statements 36/37-61
RIDADR NONH for all modes of transport
WGK Germany WGK 3
Purity ≥98% (HPLC)
Storage Temp. 2-8°C
UNSPSC 12352200

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