SGK1 (δ1-60, S422D), active human
SIGMA/S8939 - recombinant, expressed in baculovirus infected Sf9 cells (truncated human sequence (a.a. 1-60 deleted, S422D mutation)-histidine-tagged), buffered aqueous solution
MDL Number: MFCD03458482
Product Type: Chemical
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| form | buffered aqueous solution |
| mol wt | ~48 kDa by SDS-PAGE |
| Quality Level | 200  |
| recombinant | expressed in baculovirus infected Sf9 cells (truncated human sequence (a.a. 1-60 deleted, S422D mutation)-histidine-tagge |
| shipped in | dry ice |
| storage temp. | −70°C |
| UniProt accession no. | O00141  |
| Biochem/physiol Actions: | Kinase assays. |
| Biochem/physiol Actions: | The serum- and glucocorticoid-regulated kinase (SGK1) has a role in the hormonal regulation of ion channels and pumps. It has been associated with cancers. The protein modulates nitric oxide production by activating NO synthase. SGK1 protects cells from apoptosis and oxidative stress. |
| General description: | The serum- and glucocorticoid-regulated kinase (SGK1) is a member of the AGC kinase family and the gene encoding it is localized on human chromosome 6q23. |
| Legal Information: | Brij is a registered trademark of Croda International PLC |
| Other Notes: | One unit of SGK1 = 1 nmol phosphate incorporated into crosstide substrate peptide in one minute. |
| Physical form: | Solution in 50 mM Tris-HCl, pH 7.5, 0.1 mM EGTA, 0.1% β-mercaptoethanol, 0.15 M NaCl, 0.03% Brij® L23, 1 mM benzamidine, 0.2 mM PMSF. and 270 mM sucrose. |
| Safety Statements | 23-24/25 |
| WGK Germany | 2 |
| Storage Temp. | −70°C |
| UNSPSC | 51111800 |