Advanced Search



SB 220025 trihydrochloride

SIGMA/S9070 - ≥98% (HPLC), solid

Synonym: 5-(2-Aminopyrimidin-4-yl)-4-(4-fluorophenyl)-1-(4-piperidinyl)imidazole trihydrochloride

CAS Number: 197446-75-6
Empirical Formula (Hill Notation): C18H19FN6 · 3HCl
Molecular Weight: 447.76
MDL Number: MFCD08705333
Linear Formula: C18H19FN6 · 3HCl
Product Type: Chemical
Catalog Number PKG Qty. Price Quantity
45-S9070-500UG 500 µg
 $195.00
1/EA		 Add To Favorites
45-S9070-2MG 2 mg
 $461.00
1/EA		 Add To Favorites

 

assay ≥98% (HPLC)
color white
form solid
InChI 1S/C18H19FN6.3ClH/c19-13-3-1-12(2-4-13)16-17(15-7-10-22-18(20)24-15)25(11-23-16)14-5-8-21-9-6-14;;;/h1-4,7,10-11,14,21H,5-6,8-9H2,(H2,20,22,24);3*1H
InChI key IPFBHUGKKONHFR-UHFFFAOYSA-N
originator GlaxoSmithKline
Quality Level 100 
SMILES string Cl[H].Cl[H].Cl[H].Nc1nccc(n1)-c2c(ncn2C3CCNCC3)-c4ccc(F)cc4
solubility H2O: 22 mg/mL
Application: SB 220025 trihydrochloride may be used in p38-mediated cell signaling studies.
Biochem/physiol Actions: SB 220025 is a potent, specific inhibitor of human p38 MAP kinase (IC50 = 60 nM).
Biochem/physiol Actions: SB 220025 is a potent, specific inhibitor of human p38 mitogen-activated protein (MAP) kinase, with an IC50 value of 60 nM and 50- to 1000-fold selectivity. SB 220025 reduces inflammatory cytokine production and inhibits angiogenesis. SB 220025 reduced the lipopolysaccharide-induced production of TNF at an ED50 value of 7.5 mg/kg. At 30 mg/kg, SB 220025 reduced the expression of TNF and inhibited angiogenesis by ~40%. In a further study, the effects of p38/CSBP MAP kinase inhibition in angiogenesis-dependent chronic inflammatory disease was tested in murine collagen-induced arthritis and SB 220025 was able to prevent the progression of established arthritis.
Features and Benefits: This compound is featured on the MAPKs  page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here .
Features and Benefits: This compound was developed by GlaxoSmithKline . To browse the list of other pharma-developed compounds and Approved Drugs/Drug Candidates, click here .
Packaging: 2 mg in glass bottle
Packaging: 500 μg in glass bottle
Purity ≥98% (HPLC)
UNSPSC 12352200

The following items have been added to your cart:

Choose a favorite list for this item:
Catalog Number Description Price
$

Returns/Order support

Please fill out the form below if you want to request order support from Krackeler Scientific.


Quick Order

* Required


New Year Price Updates

We are currently working diligently to update our website pricing information for the New Year. If you place an order, you will be acknowledged with any corrected pricing. If you'd like the most current information sooner, please don't hesitate to drop us an email or give us a call and we'd be happy to assist. Thank you for your patience while we are updating.

800-334-7725
office@krackeler.com


Play Video

To Request a Quote

  1. Search or Browse for items and add to them to your Shopping Cart.
  2. Click the "Request Quote" button at the bottom of the Shopping Cart page.
  3. Fill out required fields.
  4. Optionally you can convert to standard checkout mode by choosing a payment type.
  5. Click "Request Quote" at the bottom of the page.

You will be contacted with a quote.

To Order From a Quote

  1. Register and login to the website.
  2. Receive a quote from your sales representative or customer service.
  3. Have your copy of the quote in hand.
  4. Visit our quote module to search for your quote.
Back to Top