Somatostatin

SIGMA/S9129 - ≥97% (HPLC), powder

Synonym: Growth hormone release inhibiting factor; SRIF; Somatostatin-14; Somatotropin release inhibiting factor

CAS Number: 38916-34-6
Empirical Formula (Hill Notation): C₇₆H₁₀₄N₁₈O₁₉S₂
Molecular Weight: 1637.88
EC Number: 254-186-5
MDL Number: MFCD00076762
Linear Formula: C₇₆H₁₀₄N₁₈O₁₉S₂
Product Type: Chemical

Catalog Number	PKG Qty.	Price


45-S9129-.5MG	0.5 mg	$105.00 1/EA	Add To Favorites
45-S9129-1MG	1 mg	$119.00 1/EA	Add To Favorites
45-S9129-5MG	5 mg	$592.00 1/EA	Add To Favorites
45-S9129-10MG	10 mg	$1030.00 1/EA	Add To Favorites

This picture is provided solely for illustration purposes. Optical properties of the actual product may deviate. Relevant product information is printed on labeled products and other accompanying or available information material. This image depicts SKU: S9129-.5MG

Properties
Descriptions
Safety Info.
Basic Data

assay	≥97% (HPLC)
form	powder
InChI	1S/C76H104N18O19S2/c1-41(79)64(100)82-37-61(99)83-58-39-114-115-40-59(76(112)113)92-72(108)57(38-95)91-75(111)63(43(3)97)94-71(107)54(33-46-23-11-6-12-24-46)90-74(110)62(42(2)96)93-66(102)51(28-16-18-30-78)84-69(105)55(34-47-36-81-49-26-14-13-25-48(47)49)88-68(104)53(32-45-21-9-5-10-22-45)86-67(103)52(31-44-19-7-4-8-20-44)87-70(106)56(35-60(80)98)89-65(101)50(85-73(58)109)27-15-17-29-77/h4-14,19-26,36,41-43,50-59,62-63,81,95-97H,15-18,27-35,37-40,77-79H2,1-3H3,(H2,80,98)(H,82,100)(H,83,99)(H,84,105)(H,85,109)(H,86,103)(H,87,106)(H,88,104)(H,89,101)(H,90,110)(H,91,111)(H,92,108)(H,93,102)(H,94,107)(H,112,113)/t41-,42+,43+,50-,51-,52-,53-,54-,55-,56-,57?,58-,59-,62-,63-/m0/s1
InChI key	NHXLMOGPVYXJNR-FQSIDJEASA-N
Quality Level	200
SMILES string	[H]N1[C@@H](Cc2ccccc2)C(=O)N[C@@H](Cc3ccccc3)C(=O)N[C@@H](Cc4c[nH]c5ccccc45)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H]([C@@H](C)O)C(=O)N[C@@H](Cc6ccccc6)C(=O)N[C@@H]([C@@H](C)O)C(=O)NC(CO)C(=O)N[C@@H](CSSC[C@H](NC(=O)CNC(=O)[C@H](C)N)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CC(N)=O)C1=O)C(O)=O
storage temp.	−20°C

Amino Acid Sequence:	Ala-Gly-Cys-Lys-Asn-Phe-Phe-Trp-Lys-Thr-Phe-Thr-Ser-Cys
Application:	Somatostatin has been used: • as a standard antigen to detect antibodies in an indirect enzyme-linked immunosorbent assay (ELISA) method • to study the effect of somatostatin on oxytocin release during pregnancy in rats • to test the specificity of the avidin-biotinylated horseradish peroxidase immunocytochemical procedure to visualize somatostatin-immunoreactive (SS-IR) neurons
Biochem/physiol Actions:	Somatostatin (SST) performs several functions like anti-proliferation, pro-apoptosis and anti-migration. Somatostatin performs physiological activities with the help of various G protein-coupled receptor subtypes (SST receptor (SSTR)-1, SSTR2A, SSTR2B, and SSTR3-5).
Biochem/physiol Actions:	Somatostatin regulates the secretion of hormones and bioactive peptides. It acts as an inhibitor in the digestive tract by inhibiting gastrin release. In the pancreatic islets, it inhibits glucagon and insulin release. Somatostatin and its synthetic analogs have been used in the treatment of neuroendocrine tumors.
General description:	Somatostatin (SST) is a peptide.
General description:	Somatostatin is expressed in endocrine cells and nerve fibers of the gastrointestinal tract. It is also expressed in other tissues.
Other Notes:	Lyophilized from 0.1% TFA in H2O
Packaging:	1, 5, 10 mg in glass bottle

RIDADR	NONH for all modes of transport
WGK Germany	WGK 3
Flash Point(F)	Not applicable
Flash Point(C)	Not applicable

Purity	≥97% (HPLC)
Storage Temp.	−20°C
UNSPSC	12352200

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