SIB 1757

SIGMA/S9186 - ≥99% (HPLC), crystalline

Synonym: 6-Methyl-2-(phenylazo)-3-pyridinol

CAS Number: 31993-01-8
Empirical Formula (Hill Notation): C₁₂H₁₁N₃O
Molecular Weight: 213.24
MDL Number: MFCD00506102
Linear Formula: C₁₂H₁₁N₃O
Product Type: Chemical

Catalog Number	PKG Qty.	Price	Quantity


45-S9186-10MG	10 mg	$122.00 1/EA		Add To Favorites

Properties
Descriptions
Safety Info.
Basic Data

assay	≥99% (HPLC)
color	red
form	crystalline
InChI	1S/C12H11N3O/c1-9-7-8-11(16)12(13-9)15-14-10-5-3-2-4-6-10/h2-8,16H,1H3/b15-14+
InChI key	LOCPVWIREQIGNQ-CCEZHUSRSA-N
Quality Level	100
SMILES string	Cc1ccc(O)c(N=Nc2ccccc2)n1

Application:	SIB 1757 may be used in mGluR5 metabotropic glutamate receptor-mediated cell signaling studies.
Biochem/physiol Actions:	SIB 1757 is a highly selective mGluR5 metabotropic glutamate receptor antagonist. It non-competitively inhibits glutamate-induced increase in Ca²⁺ at human metabotropic glutamate receptor 1 (hmGluR1).¹ Inhibition of mGlu5 receptor renders protection to neurons² against methamphetamine-induced oxidative damage.³
Features and Benefits:	This compound is featured on the Glutamate Receptors (G Protein Family) page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here .

Symbol	GHS07
Signal word	Warning
Hazard statements	H315 - H319 - H335
Precautionary statements	P302 + P352 - P305 + P351 + P338
Hazard Codes	Xi
Risk Statements	36/37/38
Safety Statements	26-36
RIDADR	NONH for all modes of transport
WGK Germany	WGK 3
Flash Point(F)	Not applicable
Flash Point(C)	Not applicable

Purity	≥99% (HPLC)
UNSPSC	12352202

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