Sphingosine Kinase 1 human
SIGMA/S9446 - aqueous glycerol solution
Synonym: SPHK 1
MDL Number: MFCD09265456
Product Type: Chemical
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| form | solution |
| mol wt | 47 kDa |
| Quality Level | 200  |
| recombinant | expressed in baculovirus infected insect cells |
| shipped in | dry ice |
| specific activity | ≥10 units/μg |
| storage temp. | −70°C |
| UniProt accession no. | Q9NYA1  |
| Application: | Sphingosine kinase 1 has been used in a study to assess the modulation of cellular S1P levels. Sphingosine kinase 1 has also been used in a study to investigate how FTY720 normalizes hyperglycemia. |
| Biochem/physiol Actions: | Converts sphingosine to sphingosine-1-phosphate. SPHK1 shares two large conserved regions with SPHK2. While SPHK1 is found only in the cytosol, SPHK2 is localized in both the cytosol and nuclei. |
| General description: | Sphingosine 1-phosphate-induced release of TIMP-2 from vascular smooth muscle cells inhibits angiogenesis. |
| Other Notes: | One unit will produce 1.0 pmole of sphingosine-1-phosphate from ATP and D-erythro-sphingosine per minute at pH 7.4, 37 °C. |
| Physical form: | aqueous glycerol solution |
| Physical form: | Supplied in 25 mM Tris-HCl, pH 8.0, 100 mM NaCl, 0.05% Tween 20, 50% glycerol, 3 mM DTT. |
| RIDADR | NONH for all modes of transport |
| WGK Germany | WGK 1 |
| Flash Point(F) | Not applicable |
| Flash Point(C) | Not applicable |
| activity | specific activity: ≥10 units/μg |
| Storage Temp. | −70°C |
| Enzyme Commission (EC) Number | 2.7.1.91 ( BRENDA | IUBMB ) |
| UNSPSC | 12352204 |