Amyloid Precursor Protein α, Secreted human
SIGMA/S9564 - >90% (SDS-PAGE), recombinant, expressed in E. coli (N-terminal histidine tagged), buffered aqueous solution
Synonym: sAPPα
MDL Number: MFCD03454663
Product Type: Chemical
SDS-PAGE Amyloid Precursor Protein α, Secreted human (Cat. No. S9564) was assessed on SDS-PAGE.
| assay | >90% (SDS-PAGE) |
| form | buffered aqueous solution |
| mol wt | ~100 kDa by SDS-PAGE |
| Quality Level | 200  |
| recombinant | expressed in E. coli (N-terminal histidine tagged) |
| shipped in | dry ice |
| storage temp. | −70°C |
| UniProt accession no. | P05067  |
| Application: | Human amyloid precursor protein α secreted, has been used in enzyme linked immunosorbent assay (ELISA). |
| Biochem/physiol Actions: | Amyloid precursor protein α is an α-secretase-cleaved soluble protein that has been shown to have neuroprotective properties. It is derived from amyloid precursor protein. The protein consists of 612 amino acids. Several G protein-coupled receptors are known to activate α-secretase-dependent processing of APP. It has neuroprotective, neurogenic and neurotrophic functions. Amyloid precursor protein a also stimulates gene expression and protein expression. |
| General description: | The APP (amyloid precursor protein) gene is mapped to human chromosome 21q21.3. It encodes a integral membrane protein. APPα is a soluble protein generated by sequential cleavage with α and γ secretase. |
| Physical form: | Solution 0.2 μm filtered, in phosphate buffered saline, pH 7.4. |
| Preparation Note: | Expressed as a soluble protein and purified under non-denaturing conditions. |
| RIDADR | NONH for all modes of transport |
| WGK Germany | nwg |
| Flash Point(F) | Not applicable |
| Flash Point(C) | Not applicable |
| Purity | >90% (SDS-PAGE) |
| Storage Temp. | −70°C |
| UNSPSC | 12352202 |