Anti-SNK (C-term) antibody produced in rabbit
SIGMA/SAB1300018 - IgG fraction of antiserum, buffered aqueous solution
Synonym: Anti-PLK-2; Anti-Polo-like kinase 1; Anti-
Product Type: Chemical
Immunohistochemistry Anti-SNK (C-term) Antibody: Cat. No. SAB1300018: SNK in human breast carcinoma tissue with Anti-SNK (C-term) Antibody at 40 μg/mL.
Immunoblotting Anti-SNK (C-term) Antibody: Cat. No. SAB1300018: SNK in PMA-treated Pam212 cell line (lane 1) and Rat testis tissue (lane 2) lysate with Anti-SNK (C-term) Antibody at 4.0 μg/mL.
| antibody form | IgG fraction of antiserum |
| antibody product type | primary antibodies |
| biological source | rabbit |
| clone | polyclonal |
| conjugate | unconjugated |
| form | buffered aqueous solution |
| NCBI accession no. | NP_006613   |
| Quality Level | 200 |
| shipped in | dry ice |
| species reactivity | mouse, human, rat |
| storage temp. | −20°C |
| target post-translational modification | unmodified |
| technique(s) | immunohistochemistry: 1:50-1:100 |
| indirect ELISA: 1:1000 | |
| western blot: 1:100-1:500 | |
| UniProt accession no. | Q9NYY3 |
| General description: | Plks (polo-like kinases) encode serine/threonine kinases that are closely related to polo and CDC5, genes that are required for passage through mitosis in Drosophila and Saccharomyces, respectively. Polo-like kinases, which include Plk, Snk (for serum-inducible kinase, also designated Plk2) and Fnk (for FGF-inducible kinase, also designated Plk3 or PRK), play a role in cell proliferation. Plk protein accumulates in the cell during S and G2 phases of the cell cycle, and both protein content and catalytic activity peak at the onset of mitosis, followed by a rapid reduction after mitosis. Snk and Fnk are immediate-early response genes that are first expressed during G1 phase. SNK may play a role in the division of at least some cell types, such as fibroblasts, and could function in embryogenesis, wound healing or neoplasia SNK mRNA is rapidly induced in human lung fibroblasts upon reintroduction of serum following 36 hours of serum deprivation. |
| Immunogen: | SNK (NP_006613, 380-416) This antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide selected from the C-terminal region of human SNK. |
| Physical form: | Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. |
| RIDADR | NONH for all modes of transport |
| WGK Germany | nwg |
| Flash Point(F) | Not applicable |
| Flash Point(C) | Not applicable |
| Storage Temp. | −20°C |
| UNSPSC | 12352203 |