Anti-Cry2 (C-term) antibody produced in rabbit

SIGMA/SAB1300079 - IgG fraction of antiserum, buffered aqueous solution

Synonym: Anti-HCRY2; Anti-PHLL2

Product Type: Chemical

Catalog Number	PKG Qty.	Price


45-SAB1300079-100UG	100 µg	$488.00 1/EA	Add To Favorites

Immunohistochemistry Anti-CRY2 (C-term) Antibody: Cat. No. SAB1300079: CRY2 in human breast carcinoma tissue with Anti-CRY2 (C-term) Antibody at 40 μg/mL.

Immunoblotting Anti-CRY2 (C-term) Antibody: Cat. No. SAB1300079: CRY2 in mouse liver tissue lysates with Anti-CRY2 (C-term) Antibody at 4.0 μg/mL.

Properties
Descriptions
Safety Info.
Basic Data

antibody form	IgG fraction of antiserum
antibody product type	primary antibodies
biological source	rabbit
clone	polyclonal
conjugate	unconjugated
form	buffered aqueous solution
NCBI accession no.	NP_066940
Quality Level	100
shipped in	dry ice
species reactivity	human, mouse
storage temp.	−20°C
target post-translational modification	unmodified
technique(s)	immunohistochemistry: 1:50-1:100
	indirect ELISA: 1:1000
	western blot: 1:100-1:500
UniProt accession no.	Q49AN0

Disclaimer:	Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
General description:	Various biochemical, physiological and behavioural processes display circadian rhythms controlled by an internal biological clock. The central "gears" driving this clock appear to be composed of an autoregulatory transcription/posttranslation-based feedback loop. Cryptochrome 1 (CRY1) and 2 (CRY2) are DNA-binding flavoproteins that bear some homology to blue-light receptors and photolyases. In Drosophila, CRY is a photoreceptor for the circadian clock where it binds to the clock component TIM in a light-dependent fashion and blocks its function. Mammalian CRY1 and CRY2 function via light-independent interactions with circadian genes CLOCK and BMAL1, as well as with PER1, PER2, and TIM. They seem to act as light-independent components of the circadian clock and likely regulate Per1 transcriptional cycling via interactions with both the activator and its feedback inhibitors. Mutant mice not expressing the Cry1 or Cry2 protein display accelerated and delayed periodicity of locomotor activity, respectively. It appears that the combination of both proteins working together is essential to synchronize the organism to circadian phases. A critical balance between Cry1 and Cry2 is required for proper clock function; in complete darkness, double-mutant mice present with instantaneous arrhythmicity, indicating the absence of an internal circadian clock.
Immunogen:	CRY2 (NP_066940, 569-603) This antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide selected from the C-terminal region of human CRY2.
Physical form:	Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide.

RIDADR	NONH for all modes of transport
WGK Germany	nwg

Storage Temp.	−20°C
UNSPSC	12352203

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