Anti-TGFBR1 (center) antibody produced in rabbit
SIGMA/SAB1300113 - IgG fraction of antiserum, buffered aqueous solution
Synonym: TGF-β receptor type I, TGFR-1, TGF-β type I receptor, Serine/
Product Type: Chemical
Immunohistochemistry Anti-TGFBR1 (Center) Antibody: Cat. No. SAB1300113: TGFBR1 in human hepatocarcinoma tissue with Anti-TGFBR1 (Center) Antibody at 40 μg/mL.
Immunoblotting Anti-TGFBR1 (Center) Antibody: Cat. No. SAB1300113: TGFBR1 in mouse small intestine tissue lysates with Anti-TGFBR1 (Center) Antibody at 4.0 μg/mL.
Immunoblotting Anti-TGFBR1 (Center) Antibody: Cat. No. SAB1300113: TGFBR1 in Jurkat cell line lysates with Anti-TGFBR1 (Center) Antibody at 4.0 μg/mL.
| antibody form | IgG fraction of antiserum |
| antibody product type | primary antibodies |
| biological source | rabbit |
| clone | polyclonal |
| conjugate | unconjugated |
| form | buffered aqueous solution |
| NCBI accession no. | NP_004603   |
| Quality Level | 100 |
| shipped in | dry ice |
| species reactivity | human, mouse |
| storage temp. | −20°C |
| target post-translational modification | unmodified |
| technique(s) | immunohistochemistry: 1:50-1:100 |
| indirect ELISA: 1:1000 | |
| western blot: 1:100-1:500 | |
| UniProt accession no. | P36897 |
| Application: | Anti-TGFBR1 (center) antibody produced in rabbit has been used in western blot. |
| Biochem/physiol Actions: | TGFBR1 (transforming growth factor β receptor 1) stimulates signaling pathway that mediates cell growth and division. The complex formed by TGFBR2 with TGFBR1 results in the phosphorylation and activation of TGFBR1. TGFBR1 is responsible for the activation of canonical Smad (mothers against decapentaplegic homolog 3) proteins and transcriptional factors Snail (zinc finger protein) and Twist (twist family bHLH transcription factor 1). The activation of a number of non-canonical effectors such as RhoA (ras homolog family member A), TAK1 (transforming growth factor-β-activated kinase 1) and Akt (RAC-α serine/threonine-protein kinase) is also associated with TGFBR1. The arrangement of the TGFBR1 receptor along with TGFBR2 at the focal adhesions mediates the multimerization and stimulation of TGFβ ligand. Downregulation of TGFBR1 is observed in breast cancer. TGFBR1 is also known to be associated with colorectal cancer. |
| Disclaimer: | Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals. |
| General description: | TGFBR1 (transforming growth factor β receptor 1) gene is mapped to human chromosome 9q22.33. TGFBR1 is known to localize in the focal adhesions of the cell surface. |
| General description: | The protein encoded by this gene forms a heteromeric complex with type II TGF-β receptors when bound to TGF-beta, transducing the TGF-beta signal from the cell surface to the cytoplasm. The encoded protein is a serine/threonine protein kinase. Mutations in this gene have been associated with Loeys-Dietz aortic aneurysm syndrome (LDAS). |
| Immunogen: | TGFBR1 (NP_004603, 138-173) This antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide selected from the central region of human TGFBR1. |
| Physical form: | Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. |
| RIDADR | NONH for all modes of transport |
| WGK Germany | nwg |
| Flash Point(F) | Not applicable |
| Flash Point(C) | Not applicable |
| Storage Temp. | −20°C |
| UNSPSC | 12352203 |