Monoclonal Anti-SET07 antibody produced in mouse
SIGMA/SAB1300134 - purified immunoglobulin, buffered aqueous solution
Synonym: Anti-H4-K20-HMTase; Anti-Histone H4-K20 methyltransferase; Anti-PR/SET07; PR/SET domain-containing protein 07; SET domain-containing protein 8
Product Type: Chemical
Immunoblotting Anti-SET07 Antibody: Cat. No. SAB1300134: SET07 in HEK 293 cell line lysates with Anti-SET07 Antibody at 4.0 μg/mL.
| antibody form | purified immunoglobulin |
| antibody product type | primary antibodies |
| biological source | mouse |
| clone | 43AT890, monoclonal |
| conjugate | unconjugated |
| form | buffered aqueous solution |
| isotype | IgG1 |
| NCBI accession no. | AAF97812   |
| Quality Level | 100 |
| shipped in | dry ice |
| species reactivity | human, mouse |
| storage temp. | −20°C |
| target post-translational modification | unmodified |
| technique(s) | indirect ELISA: 1:1000 |
| western blot: 1:100-1:500 | |
| UniProt accession no. | Q9NQR1 |
| General description: | SET07 is a histone methyltransferase that methylates Lys-20 of histone H4. H4 Lys-20 methylation represents a specific tag for epigenetic transcriptional repression. The nuclear SET07 protein, which associates with silent chromatin on euchromatic arms but shows no association with constitutive heterochromatin, prefers nucleosomes as substrate compared to free histones. It appears that SET07 may play a role in maintaining silent chromatin by preventing neighboring acetylation of H4 tail. Although the SET domain contains the active site of enzymatic activity, both sequences upstream and downstream of the SET domain are required for methyltransferase activity. |
| Immunogen: | SET07 (AAF97812, N Terminal) This antibody was raised using purified recombinant GST fusion protein encoding N-terminal of human SET07. |
| Physical form: | Purified monoclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. |
| RIDADR | NONH for all modes of transport |
| WGK Germany | nwg |
| Flash Point(F) | Not applicable |
| Flash Point(C) | Not applicable |
| Storage Temp. | −20°C |
| UNSPSC | 12352203 |