Anti-Phospho-INSR-Y1361 antibody produced in rabbit
SIGMA/SAB1300309 - affinity isolated antibody, buffered aqueous solution
Synonym: Anti-CD220 antigen; Anti-INSR; Anti-IR; Anti-Insulin receptor [Precursor]
Product Type: Chemical
Immunohistochemistry Anti-Phospho-INSR-Y1361 Antibody: Cat. No. SAB1300309: INSR in human breast carcinoma tissue with Anti-Phospho-INSR-Y1361 Antibody at 40 μg/mL.
Immunoblotting Dot blot analysis of Anti-Phospho-INSR-Y1361 Antibody: Cat No. SAB1300309: Anti-Phospho-INSR-Y1361 Antibody with Phospho-peptide or Non Phospho-peptide at 0.5 μg/mL.
| antibody form | affinity isolated antibody |
| antibody product type | primary antibodies |
| biological source | rabbit |
| clone | polyclonal |
| conjugate | unconjugated |
| form | buffered aqueous solution |
| NCBI accession no. | NP_000199   |
| Quality Level | 100 |
| shipped in | dry ice |
| species reactivity | human |
| storage temp. | −20°C |
| target post-translational modification | phosphorylation (pTyr1361) |
| technique(s) | dot blot: suitable |
| immunohistochemistry: 1:50-1:100 | |
| indirect ELISA: 1:1000 | |
| UniProt accession no. | P06213 |
| Disclaimer: | Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals. |
| General description: | After removal of the precursor signal peptide, the insulin receptor precursor is post-translationally cleaved into two chains (alpha and beta) that are covalently linked. Binding of insulin to the insulin receptor (INSR) stimulates glucose uptake, thereby mediating the metabolic functions of insulin. Binding to insulin stimulates association of the receptor with downstream mediators including IRS1 and phosphatidylinositol 3′-kinase (PI3K). This protein can activate PI3K either directly by binding to the p85 regulatory subunit, or indirectly via IRS1. |
| Immunogen: | INSR (NP_000199, ) This antibody is generated from rabbits immunized with a KLH conjugated synthetic phosphopeptide corresponding to amino acid residues surrounding Y1361 of human INSR. |
| Physical form: | Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. |
| RIDADR | NONH for all modes of transport |
| WGK Germany | WGK 1 |
| Flash Point(F) | Not applicable |
| Flash Point(C) | Not applicable |
| Storage Temp. | −20°C |
| UNSPSC | 12352203 |