Anti-DGKZ (C-term) antibody produced in rabbit
SIGMA/SAB1300449 - IgG fraction of antiserum, buffered aqueous solution
Synonym: Anti-ζ; Anti-DAG kinase ζ; Anti-DGK-ζ; Anti-Diacylglycerol kinase; Anti-Diglyceride kinase
Product Type: Chemical
Immunohistochemistry Anti-DGKZ (C-term) Antibody: Cat. No. SAB1300449: DGKZ in human hepatocarcinoma tissue with Anti-DGKZ (C-term) Antibody at 40 μg/mL.
Immunoblotting Anti-DGKZ (C-term) Antibody: Cat. No. SAB1300449: DGKZ in HEK 293 cell line lysates either non-transfected (Lane 1) or transiently transfected (Lane 2) with Anti-DGKZ (C-term) Antibody at 4.0 μg/mL.
| antibody form | IgG fraction of antiserum |
| antibody product type | primary antibodies |
| biological source | rabbit |
| clone | polyclonal |
| conjugate | unconjugated |
| form | buffered aqueous solution |
| NCBI accession no. | NP_963290   |
| Quality Level | 100 |
| shipped in | dry ice |
| species reactivity | human |
| storage temp. | −20°C |
| target post-translational modification | unmodified |
| technique(s) | immunohistochemistry: 1:50-1:100 |
| indirect ELISA: 1:1000 | |
| western blot: 1:100-1:500 | |
| UniProt accession no. | Q13574 |
| Biochem/physiol Actions: | Diacylglycerol kinase zeta ζ (DGKZ) plays a key role in brain development. It mediates the conversion of diacylglycerol to phosphatidic acid. Elevated DGKZ levels is observed in human metastatic colon cancer. DGKZ protein defects are implicated in osteogenesis imperfecta (OI) leading to a phenotype characterized by fractures in utero and after birth, callus formation, and beaded ribs. DGKZ also regulates bone homeostasis. Knockdown of the DGKζ gene leads to cell cycle arrest and apoptosis in glioma cells. |
| Disclaimer: | Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals. |
| General description: | Diacylglycerol kinase zeta ζ (DGKZ) belongs to the diacylglycerol kinase family. It is expressed in the central nervous system and comprises a nuclear localization signal, ankyrin repeats, and a PDZ-binding motif. DGKZ gene is localized on human chromosome 11p11.2. |
| Immunogen: | DGKZ (NP_963290, 994-1029) This antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide selected from the C-terminal region of human DGKZ. |
| Physical form: | Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. |
| RIDADR | NONH for all modes of transport |
| WGK Germany | nwg |
| Flash Point(F) | Not applicable |
| Flash Point(C) | Not applicable |
| Storage Temp. | −20°C |
| UNSPSC | 12352203 |