Anti-USP12 (N-term) antibody produced in rabbit

SIGMA/SAB1300639 - IgG fraction of antiserum, buffered aqueous solution

Synonym: Anti-Ubiquitin carboxyl-terminal hydrolase 12; Anti-Ubiquitin thiolesterase 12; Anti-Ubiquitin-specific processing protease 12; Deubiquitinating enzyme 12; Ubiquitin hydrolyzing enzyme 1

Product Type: Chemical

Catalog Number	PKG Qty.	Price


45-SAB1300639-100UG	100 µg	$488.00 1/EA	Add To Favorites

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Properties
Descriptions
Safety Info.
Basic Data

antibody form	IgG fraction of antiserum
antibody product type	primary antibodies
biological source	rabbit
clone	polyclonal
conjugate	unconjugated
form	buffered aqueous solution
NCBI accession no.	NP_872294
Quality Level	200
shipped in	dry ice
species reactivity	human, mouse
storage temp.	−20°C
target post-translational modification	unmodified
technique(s)	immunohistochemistry: 1:50-1:100
	indirect ELISA: 1:1000
	western blot: 1:100-1:500
UniProt accession no.	P51784

Disclaimer:	Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
General description:	Modification of target proteins by ubiquitin participates in a wide array of biological functions. Proteins destined for degradation or processing via the 26 S proteasome are coupled to multiple copies of ubiquitin. However, attachment of ubiquitin or ubiquitin-related molecules may also result in changes in subcellular distribution or modification of protein activity. An additional level of ubiquitin regulation, deubiquitination, is catalyzed by proteases called deubiquitinating enzymes, which fall into four distinct families. Ubiquitin C-terminal hydrolases, ubiquitin-specific processing proteases (USPs),1 OTU-domain ubiquitin-aldehyde-binding proteins, and Jab1/Pad1/MPN-domain-containing metallo-enzymes. Among these four families, USPs represent the most widespread and represented deubiquitinating enzymes across evolution. USPs tend to release ubiquitin from a conjugated protein. They display similar catalytic domains containing conserved Cys and His boxes but divergent N-terminal and occasionally C-terminal extensions, which are thought to function in substrate recognition, subcellular localization, and protein-protein interactions.
Immunogen:	USP12 (UB12_HUMAN, 5-35) This antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide selected from the N-terminal region of human USP12.
Physical form:	Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide.

RIDADR	NONH for all modes of transport
WGK Germany	nwg
Flash Point(F)	Not applicable
Flash Point(C)	Not applicable

Storage Temp.	−20°C
UNSPSC	12352203

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