Anti-MSH3 (center) antibody produced in rabbit
SIGMA/SAB1300711 - saturated ammonium sulfate (SAS) precipitated, buffered aqueous solution
Synonym: Anti-DNA mismatch repair protein Msh3; Anti-DUP; Anti-Divergent upstream protein; Anti-MRP1; Mismatch repair protein 1
Product Type: Chemical
Immunoblotting Anti-MSH3 (Center) Antibody: Cat. No. SAB1300711: MSH3 in Ramos cell line lysates with Anti-MSH3 (Center) Antibody at 4.0 μg/mL.
| antibody form | saturated ammonium sulfate (SAS) precipitated |
| antibody product type | primary antibodies |
| biological source | rabbit |
| clone | polyclonal |
| conjugate | unconjugated |
| form | buffered aqueous solution |
| NCBI accession no. | NP_002430   |
| Quality Level | 100 |
| shipped in | dry ice |
| species reactivity | human |
| storage temp. | −20°C |
| target post-translational modification | unmodified |
| technique(s) | indirect ELISA: 1:1000 |
| western blot: 1:100-1:500 | |
| UniProt accession no. | P20585 |
| General description: | MSH3 is a component of the post-replicative DNA mismatch repair system (MMR). THis protein heterodimerizes with MSH2 to form MutS beta which binds to DNA mismatches thereby initiating DNA repair. When bound, the MutS beta heterodimer bends the DNA helix and shields approximately 20 base pairs. MutS beta recognizes large insertion-deletion loops (IDL) up to 13 nucleotides long. After mismatch binding, it forms a ternary complex with the MutL alpha heterodimer, which is thought to be responsible for directing the downstream MMR events, including strand discrimination, excision, and resynthesis. |
| Immunogen: | MSH3 (NP_002430, 464-497) This antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide selected from the Center region of human MSH3. |
| Physical form: | Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. |
| RIDADR | NONH for all modes of transport |
| WGK Germany | nwg |
| Flash Point(F) | Not applicable |
| Flash Point(C) | Not applicable |
| Storage Temp. | −20°C |
| UNSPSC | 12352203 |