Anti-MCK10 antibody produced in rabbit
SIGMA/SAB1300892 - saturated ammonium sulfate (SAS) precipitated, buffered aqueous solution
Synonym: Anti-Cell adhesion kinase; Anti-Discoidin receptor tyrosine kinase isoform a; Anti-Epithelial discoidin domain receptor 1; Anti-PTK3A protein tyrosine kinase 3A; neurotrophic tyrosine kinase, receptor, type 4
Product Type: Chemical
Immunohistochemistry Anti-MCK10 Antibody: Cat. No. SAB1300892: MCK10 in human lung carcinoma tissue with Anti-MCK10 Antibody at 40 μg/mL.
Immunoblotting Anti-MCK10 Antibody: Cat. No. SAB1300892: MCK10 in SK-BR-3 cell line lysates with Anti-MCK10 Antibody at 4.0 μg/mL.
| antibody form | saturated ammonium sulfate (SAS) precipitated |
| antibody product type | primary antibodies |
| biological source | rabbit |
| clone | polyclonal |
| conjugate | unconjugated |
| form | buffered aqueous solution |
| NCBI accession no. | NP_054699   |
| Quality Level | 100 |
| shipped in | dry ice |
| species reactivity | human |
| storage temp. | −20°C |
| target post-translational modification | unmodified |
| technique(s) | immunohistochemistry: 1:50-1:100 |
| indirect ELISA: 1:1000 | |
| western blot: 1:100-1:500 | |
| UniProt accession no. | Q08345 |
| General description: | Receptor tyrosine kinases (RTKs) play a key role in the communication of cells with their microenvironment. These molecules are involved in the regulation of cell growth, differentiation and metabolism. MCK10 is a RTK that is widely expressed in normal and transformed epithelial cells and is activated by various types of collagen. This protein belongs to a subfamily of tyrosine kinase receptors with a homology region to the Dictyostelium discoideum protein discoidin I in their extracellular domain. Its autophosphorylation is achieved by all collagens so far tested (type I to type VI). In situ studies and Northern-blot analysis showed that expression of this encoded protein is restricted to epithelial cells, particularly in the kidney, lung, gastrointestinal tract, and brain. In addition, this protein is significantly over-expressed in several human tumors from breast, ovarian, esophageal, and pediatric brain. |
| Immunogen: | MCK10 (NP_054699, ) This antibody is generated from rabbits immunized with recombinant human MCK10 protein. |
| Physical form: | Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. |
| RIDADR | NONH for all modes of transport |
| WGK Germany | nwg |
| Flash Point(F) | Not applicable |
| Flash Point(C) | Not applicable |
| Storage Temp. | −20°C |
| UNSPSC | 12352203 |