ANTI-MOUSE MLKL (C-TERM) antibody produced in rabbit
SIGMA/SAB1302339 - IgG fraction of antiserum, buffered aqueous solution
Synonym: Mixed lineage kinase domain-like protein; Mlkl
Product Type: Chemical
Immunoblotting Anti-Mouse Mlkl (C-term): Cat. No. SAB1302339: Mouse Mlkl Antibody (C-term) western blot analysis in mouse NIH-3T3 cell line lysates (35 μg/lane).
| antibody form | IgG fraction of antiserum |
| antibody product type | primary antibodies |
| biological source | rabbit |
| clone | polyclonal |
| conjugate | unconjugated |
| form | buffered aqueous solution |
| mol wt | 54317 Da |
| NCBI accession no. | NP_083281.1   |
| Quality Level | 100 |
| shipped in | wet ice |
| species reactivity | mouse |
| storage temp. | −20°C |
| target post-translational modification | unmodified |
| technique(s) | western blot: 1:250-1:500 |
| UniProt accession no. | Q9D2Y4 |
| Application: | Anti mouse MLKL (C-TERM) antibody produced in rabbit has been used in immunoblotting. |
| Application: | Applications in which this antibody has been used successfully, and the associated peer-reviewed papers, are given below. Western Blotting (1 paper) |
| Biochem/physiol Actions: | Mixed lineage kinase domain-like protein (MLKL) primarily causes receptor-interacting protein (RIP) kinase–dependent necroptosis. However, during hepatitis, it results in programmed hepatocellular necrosis which is independent of RIPK3. MLKL also participates in endosomal trafficking and in the formation of extracellular vesicles. |
| Disclaimer: | Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals. |
| General description: | The gene mixed lineage kinase domain-like protein (MLKL) is mapped to human chromosome 16q23. Activated MLKL is localized on the cell membrane. |
| Physical form: | Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification. |
| RIDADR | NONH for all modes of transport |
| WGK Germany | nwg |
| Flash Point(F) | Not applicable |
| Flash Point(C) | Not applicable |
| Storage Temp. | −20°C |
| UNSPSC | 12352203 |