ANTI-USP51 (CENTER) antibody produced in rabbit
SIGMA/SAB1305451 - affinity isolated antibody, buffered aqueous solution
Synonym: Deubiquitinating enzyme 51; USP51; Ubiquitin carboxyl-terminal hydrolase 51; Ubiquitin carboxyl-terminal hydrolase 51; Ubiquitin carboxyl-terminal hydrolase 51
Product Type: Chemical
Immunoblotting Anti-USP51 (Center): Cat. No. SAB1305451: USP51 Antibody (Center) western blot analysis in HepG2,MCF-7 cell line lysates (35 μg/lane).
| antibody form | affinity isolated antibody |
| antibody product type | primary antibodies |
| biological source | rabbit |
| clone | polyclonal |
| conjugate | unconjugated |
| form | buffered aqueous solution |
| mol wt | 79756 Da |
| NCBI accession no. | NP_958443.1   |
| Quality Level | 100 |
| shipped in | wet ice |
| species reactivity | human |
| storage temp. | −20°C |
| target post-translational modification | unmodified |
| technique(s) | western blot: 1:1000 |
| UniProt accession no. | Q70EK9 |
| Biochem/physiol Actions: | Ubiquitin specific peptidase 51 (USP51) in response to DNA damage deubiquitylates histone H2A at Lys13,15 (H2AK13,15ub) present at DNA double-strand breaks (DSBs) to maintain genome integrity. High expression of USP51 suppresses ionizing radiations induced damage on p53-binding protein 1(53BP1) and breast cancer type 1 susceptibility protein (BRCA1). Cells depleted with USP51 show an increase in G1 phase cells and decrease in S-phase cells and hence it is required for cell cycle progression. USP51 deubiquitinase zinc finger E-Box binding homeobox 1)(ZEB1) and stabilizes its expression, especially in breast tumour cells. |
| Disclaimer: | Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals. |
| General description: | Ubiquitin specific peptidase 51 (USP51) encodes a deubiquitylating enzyme. USP51 is predominantly expressed in prostate, brain, lung, aorta and kidney. In human chromosome, the gene USP51 is localized on Xp11. |
| Physical form: | Supplied in PBS with 0.09% (W/V) sodium azide |
| RIDADR | NONH for all modes of transport |
| Flash Point(F) | Not applicable |
| Flash Point(C) | Not applicable |
| Storage Temp. | −20°C |
| UNSPSC | 12352203 |