Anti-CISH antibody produced in rabbit
SIGMA/SAB1400050 - IgG fraction of antiserum, buffered aqueous solution
Synonym: Anti-CIS; Anti-CIS-1; Anti-G18; Anti-SOCS
MDL Number: MFCD03096718
Product Type: Chemical
Immunofluorescence Immunofluorescence of antibody to CISH on HeLa cell. [antibody concentration 10 μg/mL]
Western Blotting Western Blot analysis of CISH expression in transfected 293T cell line by CISH polyclonal antibody. Lanes Lane 1: CISH transfected lysate (28.70 kDa). Lane 2: Non-transfected lysate.
| antibody form | IgG fraction of antiserum |
| antibody product type | primary antibodies |
| biological source | rabbit |
| clone | polyclonal |
| conjugate | unconjugated |
| form | buffered aqueous solution |
| Quality Level | 100  |
| shipped in | dry ice |
| species reactivity | human |
| storage temp. | −20°C |
| target post-translational modification | unmodified |
| technique(s) | immunofluorescence: suitable |
| western blot: 1 μg/mL | |
| UniProt accession no. | Q9NSE2  |
| General description: | The protein encoded by this gene contains a SH2 domain and a SOCS box domain. The protein thus belongs to the cytokine-induced STAT inhibitor (CIS), also known as suppressor of cytokine signaling (SOCS) or STAT-induced STAT inhibitor (SSI), protein family. CIS family members are known to be cytokine-inducible negative regulators of cytokine signaling. The expression of this gene can be induced by IL2, IL3, GM-CSF and EPO in hematopoietic cells. Proteasome-mediated degradation of this protein has been shown to be involved in the inactivation of the erythropoietin receptor. Multiple transcript variants encoding different isoforms have been found for this gene. (provided by RefSeq) |
| Immunogen: | CISH (NP_659508.1, 1 a.a. ~ 258 a.a) full-length human protein. Sequence MVLCVQGPRPLLAVERTGQRPLWAP |
| Physical form: | Solution in phosphate buffered saline, pH 7.4 |
| RIDADR | NONH for all modes of transport |
| Flash Point(F) | Not applicable |
| Flash Point(C) | Not applicable |
| Storage Temp. | −20°C |
| UNSPSC | 12352203 |