Anti-GATM antibody produced in mouse
SIGMA/SAB1400106 - IgG fraction of antiserum, buffered aqueous solution
Synonym: Anti-AGAT; Anti-AT
MDL Number: MFCD01633065
Product Type: Chemical
Western Blotting Western Blot analysis of GATM expression in transfected 293T cell line by GATM polyclonal antibody. Lanes Lane 1: GATM transfected lysate (46.53 kDa). Lane 2: Non-transfected lysate.
Western Blotting GATM polyclonal antibody. Western Blot analysis of GATM expression in human liver.
| antibody form | IgG fraction of antiserum |
| antibody product type | primary antibodies |
| biological source | mouse |
| clone | polyclonal |
| conjugate | unconjugated |
| form | buffered aqueous solution |
| Quality Level | 100  |
| shipped in | dry ice |
| species reactivity | human |
| storage temp. | −20°C |
| target post-translational modification | unmodified |
| technique(s) | western blot: 1 μg/mL |
| UniProt accession no. | P50440  |
| Biochem/physiol Actions: | Glycine amidinotransferase (GATM) is involved in the formation of ornithine and guanidinoacetate from arginine and glycine. This is an important step in creatine synthesis. Mutations in the gene encoding GATM have been shown to lead to arginine-glycine amidinotransferase deficiency. |
| General description: | This gene encodes a mitochondrial enzyme that belongs to the amidinotransferase family. This enzyme is involved in creatine biosynthesis, whereby it catalyzes the transfer of a guanido group from L-arginine to glycine, resulting in guanidinoacetic acid, the immediate precursor of creatine. Mutations in this gene cause arginine:glycine amidinotransferase deficiency, an inborn error of creatine synthesis characterized by mental retardation, language impairment, and behavioral disorders. (provided by RefSeq) |
| Immunogen: | GATM (NP_001473.1, 1 a.a. ~ 423 a.a) full-length human protein. Sequence MLRVRCLRGGSRGAEAVHYIGSRLG |
| Physical form: | Solution in phosphate buffered saline, pH 7.4 |
| RIDADR | NONH for all modes of transport |
| Flash Point(F) | Not applicable |
| Flash Point(C) | Not applicable |
| Storage Temp. | −20°C |
| UNSPSC | 12352203 |