Anti-HIRA antibody produced in mouse
SIGMA/SAB1400286 - IgG fraction of antiserum, buffered aqueous solution
Synonym: Anti-DGCR1; Anti-TUP1; Anti-TUPLE1
Product Type: Chemical
Immunofluorescence Immunofluorescence of antibody to HIRA on HeLa cell. [antibody concentration 10 μg/mL]
Western Blotting Western Blot analysis of HIRA expression in transfected 293T cell line by HIRA polyclonal antibody. Lanes Lane 1: HIRA transfected lysate (111.87 kDa). Lane 2: Non-transfected lysate.
| antibody form | IgG fraction of antiserum |
| antibody product type | primary antibodies |
| biological source | mouse |
| clone | polyclonal |
| conjugate | unconjugated |
| form | buffered aqueous solution |
| Quality Level | 100  |
| shipped in | dry ice |
| species reactivity | human |
| storage temp. | −20°C |
| target post-translational modification | unmodified |
| technique(s) | indirect immunofluorescence: suitable |
| western blot: 1 μg/mL | |
| UniProt accession no. | P54198  |
| Disclaimer: | Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals. |
| General description: | This gene encodes a histone chaperone that preferentially places the variant histone H3.3 in nucleosomes. Orthologs of this gene in yeast, flies, and plants are necessary for the formation of transcriptionally silent heterochomatin. This gene plays an important role in the formation of the senescence-associated heterochromatin foci. These foci likely mediate the irreversible cell cycle changes that occur in senescent cells. It is considered the primary candidate gene in some haploinsufficiency syndromes such as DiGeorge syndrome, and insufficient production of the gene may disrupt normal embryonic development. (provided by RefSeq) |
| Immunogen: | HIRA (NP_003316.3, 1 a.a. ~ 1017 a.a) full-length human protein. Sequence MKLLKPTWVNHNGKPIFSVDIHPDG |
| Physical form: | Solution in phosphate buffered saline, pH 7.4 |
| RIDADR | NONH for all modes of transport |
| Flash Point(F) | Not applicable |
| Flash Point(C) | Not applicable |
| Storage Temp. | −20°C |
| UNSPSC | 12352203 |