Anti-TXNRD1 antibody produced in mouse
SIGMA/SAB1400287 - IgG fraction of antiserum, buffered aqueous solution
Synonym: Anti-GRIM-12; Anti-MGC9145; Anti-TR; Anti-TR1; Anti-TRXR1; Anti-TXNR
Product Type: Chemical
Western Blotting TXNRD1 polyclonal antibody. Western Blot analysis of TXNRD1 expression in human kidney.
Western Blotting Western Blot analysis of TXNRD1 expression in transfected 293T cell line by TXNRD1 polyclonal antibody. Lanes Lane 1: TXNRD1 transfected lysate (54.67 kDa). Lane 2: Non-transfected lysate.
| antibody form | IgG fraction of antiserum |
| antibody product type | primary antibodies |
| biological source | mouse |
| clone | polyclonal |
| conjugate | unconjugated |
| form | buffered aqueous solution |
| Quality Level | 100  |
| shipped in | dry ice |
| species reactivity | human |
| storage temp. | −20°C |
| target post-translational modification | unmodified |
| technique(s) | western blot: 1 μg/mL |
| UniProt accession no. | Q16881  |
| Biochem/physiol Actions: | Thioredoxin reductase 1 (TNXRD1) reduces thioredoxins as well as other substrates. It plays a role in selenium metabolism and protection against oxidative stress. |
| General description: | This gene encodes a member of the family of pyridine nucleotide oxidoreductases. This protein reduces thioredoxins as well as other substrates, and plays a role in selenium metabolism and protection against oxidative stress. The functional enzyme is thought to be a homodimer which uses FAD as a cofactor. Each subunit contains a selenocysteine (Sec) residue which is required for catalytic activity. The selenocysteine is encoded by the UGA codon that normally signals translation termination. The 3′ UTR of selenocysteine-containing genes have a common stem-loop structure, the sec insertion sequence (SECIS), that is necessary for the recognition of UGA as a Sec codon rather than as a stop signal. Alternative splicing results in several transcript variants encoding the same or different isoforms. (provided by RefSeq) |
| Immunogen: | TXNRD1 (NP_877393.1, 1 a.a. ~ 497 a.a) full-length human protein. Sequence MNGPEDLPKSYDYDLIIIGGGSGGL |
| Physical form: | Solution in phosphate buffered saline, pH 7.4 |
| RIDADR | NONH for all modes of transport |
| Flash Point(F) | Not applicable |
| Flash Point(C) | Not applicable |
| Storage Temp. | −20°C |
| UNSPSC | 12352203 |