Anti-PARG antibody produced in mouse
SIGMA/SAB1400313 - IgG fraction of antiserum, buffered aqueous solution
Synonym: Anti-PARG99
Product Type: Chemical
Immunofluorescence Immunofluorescence of antibody to PARG on HeLa cell. [antibody concentration 10 μg/mL]
Western Blotting PARG polyclonal antibody. Western Blot analysis of PARG expression in HeLa S3 NE.
Western Blotting Western Blot analysis of PARG expression in transfected 293T cell line by PARG polyclonal antibody. Lanes Lane 1: PARG transfected lysate (107.36 kDa). Lane 2: Non-transfected lysate.
| antibody form | IgG fraction of antiserum |
| antibody product type | primary antibodies |
| biological source | mouse |
| clone | polyclonal |
| conjugate | unconjugated |
| form | buffered aqueous solution |
| Quality Level | 100  |
| shipped in | dry ice |
| species reactivity | human |
| storage temp. | −20°C |
| target post-translational modification | unmodified |
| technique(s) | indirect immunofluorescence: suitable |
| western blot: 1 μg/mL | |
| UniProt accession no. | Q86W56  |
| Biochem/physiol Actions: | PARG (Poly ADP-ribose glycohydrolase) is involved in several gene regulation processes such as maintenance of chromatin structure, transcription, DNA repair and apoptosis. It regulates retinoic acid receptor (RAR)-mediated transcription during chromatin remodeling. It catabolically separate ADP-ribose polymers synthesized by poly-(ADP-ribose) polymerases. A study shows that PARG plays a therapeutic role in various physiological conditions such as inflammation, ischemia, stroke, and cancer chemotherapy. |
| Disclaimer: | Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals. |
| General description: | The gene encoding PARG is localized on human chromosome 10q11.23. The enzyme has both endo- and exoglycosidase activities and exists as four isoforms. |
| Immunogen: | PARG (NP_003622.2, 1 a.a. ~ 976 a.a) full-length human protein. Sequence MNAGPGCEPCTKRPRWGAATTSPAA |
| Physical form: | Solution in phosphate buffered saline, pH 7.4 |
| RIDADR | NONH for all modes of transport |
| Flash Point(F) | Not applicable |
| Flash Point(C) | Not applicable |
| Storage Temp. | −20°C |
| UNSPSC | 12352203 |