Anti-ATAD3A antibody produced in mouse
SIGMA/SAB1400606 - IgG fraction of antiserum, buffered aqueous solution
Synonym: Anti-FLJ10709
Product Type: Chemical
Immunofluorescence Immunofluorescence of antibody to ATAD3A on HeLa cell. [antibody concentration 10 μg/mL]
Western Blotting ATAD3A polyclonal antibody. Western Blot analysis of ATAD3A expression in HeLa.
Western Blotting Western Blot analysis of ATAD3A expression in transfected 293T cell line by ATAD3A polyclonal antibody. Lanes Lane 1: ATAD3A transfected lysate (64.46 kDa). Lane 2: Non-transfected lysate.
Western Blotting ATAD3A polyclonal antibody. Western Blot analysis of ATAD3A expression in human spleen.
| antibody form | IgG fraction of antiserum |
| antibody product type | primary antibodies |
| biological source | mouse |
| clone | polyclonal |
| conjugate | unconjugated |
| form | buffered aqueous solution |
| Quality Level | 100  |
| shipped in | dry ice |
| species reactivity | human |
| storage temp. | −20°C |
| target post-translational modification | unmodified |
| technique(s) | indirect immunofluorescence: suitable |
| western blot: 1 μg/mL | |
| UniProt accession no. | Q9NVI7  |
| Biochem/physiol Actions: | ATAD3A (ATPase family, AAA domain containing 3A) was originally considered as a tumor-specific antigen. Mutation in ATAD3A is known to cause a delayed development, optic atrophy, axonal neuropathy, hypotonia and hypertrophic cardiomyopathy. ATAD3A is involved in mitochondrial development, organization of nucleoid, translation of protein, cell growth, and cholesterol metabolism. Downregulation of ATAD3A affects the mitochondrial dynamics, prevents proliferation and changes the interaction between mitochondria and the endoplasmic reticulum. Upregulation of the gene is seen in several cancer types. ATAD3A is known to offer resistance against chemotherapy and radiation. It is responsible for the mitochondrial membrane and import vesicle -mediated transport of AIF (apoptosis inducing factor) from the endoplasmic reticulum into mitochondria. Downregulation of ATAD3A promotes autophagy as well as apoptosis in uterine cervical cancer cells, and also reduces the ability to resist the anticancer drugs. ATAD3A serves as a biomarker for the prognosis of glioblastoma multiforme. It is also found to be involved in cancers such as uterine cervical cancer, lung adenocarcinoma and prostate cancer. |
| Disclaimer: | Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals. |
| General description: | ATAD3A (ATPase family, AAA domain containing 3A) is mapped to human chromosome 1p36.33. The encoded protein is a localized in mitochondrial membrane. |
| Immunogen: | ATAD3A (AAH33109.1, 1 a.a. ~ 586 a.a) full-length human protein. Sequence MSWLFGINKGPKGEGAGPPPPLPPA |
| Physical form: | Solution in phosphate buffered saline, pH 7.4 |
| RIDADR | NONH for all modes of transport |
| Flash Point(F) | Not applicable |
| Flash Point(C) | Not applicable |
| Storage Temp. | −20°C |
| UNSPSC | 12352203 |