Anti-CYC1 antibody produced in rabbit
SIGMA/SAB1401100 - purified immunoglobulin, buffered aqueous solution
Synonym: UQCR4
Product Type: Chemical
Western Blotting CYC1 rabbit polyclonal antibody. Western Blot analysis of CYC1 expression in A-431.
Western Blotting Western Blot analysis of CYC1 expression in transfected 293T cell line by CYC1 polyclonal antibody. Lanes Lane 1: CYC1 transfected lysate (35.40 kDa). Lane 2: Non-transfected lysate.
Western Blotting CYC1 rabbit polyclonal antibody. Western Blot analysis of CYC1 expression in human pancreas.
Western Blotting CYC1 rabbit polyclonal antibody. Western Blot analysis of CYC1 expression in mouse kidney.
| antibody form | purified immunoglobulin |
| antibody product type | primary antibodies |
| biological source | rabbit |
| clone | polyclonal |
| conjugate | unconjugated |
| form | buffered aqueous solution |
| NCBI accession no. | NM_001916   |
| Quality Level | 100 |
| shipped in | dry ice |
| species reactivity | mouse, human |
| storage temp. | −20°C |
| target post-translational modification | unmodified |
| technique(s) | western blot: 1 μg/mL |
| UniProt accession no. | P08574 |
| Biochem/physiol Actions: | Cytochrome c1 (CYC1) stimulates oxidative phosphorylation activity in human ductal carcinoma in- situ (DCIS) and thus, plays an essential role in cell proliferation and comedo necrosis. CYC1 expression is implicated in breast cancer progression and might act as a predictive factor for poor prognosis in breast cancer patients. Variation in the gene expression leads to mitochondrial complex III deficiency. |
| Disclaimer: | Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals. |
| General description: | Cytochrome c1 (CYC1) is a heme-containing constituent of mitochondrial complex III. It is encoded by the gene mapped to human chromosome 8q24.3. The encoded protein is attached to the phospholipid bilayer by a single C-proximal transmembrane segment. |
| Immunogen: | CYC1 (NP_001907.2, 1 a.a. ~ 325 a.a) full-length human protein. Sequence MAAAAASLRGVVLGPRGAGLPGARA |
| Physical form: | Solution in phosphate buffered saline, pH 7.4 |
| RIDADR | NONH for all modes of transport |
| Flash Point(F) | Not applicable |
| Flash Point(C) | Not applicable |
| Storage Temp. | −20°C |
| UNSPSC | 12352203 |