Anti-IFNAR2 antibody produced in rabbit
SIGMA/SAB1401203 - purified immunoglobulin, buffered aqueous solution
Synonym: IFN-R; IFN-alpha-REC; IFNABR; IFNARB
Product Type: Chemical
Western Blotting Western Blot analysis of IFNAR2 expression in transfected 293T cell line by IFNAR2 polyclonal antibody. Lanes Lane 1: IFNAR2 transfected lysate (37.40 kDa). Lane 2: Non-transfected lysate.
| antibody form | purified immunoglobulin |
| antibody product type | primary antibodies |
| biological source | rabbit |
| clone | polyclonal |
| conjugate | unconjugated |
| form | buffered aqueous solution |
| NCBI accession no. | BC002793   |
| Quality Level | 100 |
| shipped in | dry ice |
| species reactivity | human |
| storage temp. | −20°C |
| target post-translational modification | unmodified |
| technique(s) | western blot: 1 μg/mL |
| UniProt accession no. | P48551 |
| Biochem/physiol Actions: | The IFN (interferon) response is a part of the first line defense system against infection, which requires the binding of IFNs to the receptors (IFNAR1 and IFNAR2) for its activation. IFNAR2 (interferon αand βreceptor subunit 2) is associated with the JAK-STAT (Janus - signal transducer and activator of transcription) signaling pathway. |
| Disclaimer: | Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals. |
| General description: | The protein encoded by this gene is a type I membrane protein that forms one of the two chains of a receptor for interferons alpha and beta. Binding and activation of the receptor stimulates Janus protein kinases, which in turn phosphorylate several proteins, including STAT1 and STAT2. Multiple transcript variants encoding at least two different isoforms have been found for this gene. (provided by RefSeq) |
| Immunogen: | IFNAR2 (AAH02793.1, 1 a.a. ~ 331 a.a) full-length human protein. Sequence MLLSQNAFIVRSLNLVLMVYISLVF |
| Physical form: | Solution in phosphate buffered saline, pH 7.4 |
| RIDADR | NONH for all modes of transport |
| Flash Point(F) | Not applicable |
| Flash Point(C) | Not applicable |
| Storage Temp. | −20°C |
| UNSPSC | 12352203 |