Anti-IL12RB1 antibody produced in rabbit
SIGMA/SAB1401214 - purified immunoglobulin, buffered aqueous solution
Synonym: CD212; IL-12R-BETA1; IL12RB; MGC34454
Product Type: Chemical
Western Blotting Western Blot analysis of IL12RB1 expression in transfected 293T cell line by IL12RB1 polyclonal antibody. Lanes Lane 1: IL12RB1 transfected lysate (42.40 kDa). Lane 2: Non-transfected lysate.
| antibody form | purified immunoglobulin |
| antibody product type | primary antibodies |
| biological source | rabbit |
| clone | polyclonal |
| conjugate | unconjugated |
| form | buffered aqueous solution |
| NCBI accession no. | BC029121   |
| Quality Level | 100 |
| shipped in | dry ice |
| species reactivity | human |
| storage temp. | −20°C |
| target post-translational modification | unmodified |
| technique(s) | western blot: 1 μg/mL |
| UniProt accession no. | P42701 |
| Biochem/physiol Actions: | IL12RB1 (interleukin 12 receptor subunit β1) regulates the physiological responses to a number of diseases. IL12RB1 binds to both IL 12 (interleukin 12) and IL 23 (interleukin 23) at a common binding point 12p40-domain.Variation in the gene affects the receptor sensitivity towards the cytokines IL 12 and IL 23. Thus, the gene is associated with the diseases that are regulated by IL 12 and IL 23. Susceptibility to diseases such as tuberculosis, nontuberculous mycobacterial infection, malaria, cancer, pediatric asthma, and atopic dermatitis is related to IL12RB1. |
| General description: | IL12RB1 (interleukin 12 receptor subunit β1) gene is mapped to human chromosome 19p13.11. The encoded protein is a member of type I transmembrane receptors. |
| General description: | Rabbit polyclonal antibody raised against a full-length human IL12RB1 protein. |
| Immunogen: | IL12RB1 (AAH29121.1, 1 a.a. ~ 381 a.a) full-length human protein. Sequence MEPLVTWVVPLLFLFLLSRQGAACR |
| Physical form: | Solution in phosphate buffered saline, pH 7.4 |
| RIDADR | NONH for all modes of transport |
| Flash Point(F) | Not applicable |
| Flash Point(C) | Not applicable |
| Storage Temp. | −20°C |
| UNSPSC | 12352203 |