Anti-TFAM antibody produced in mouse
SIGMA/SAB1401382 - purified immunoglobulin, buffered aqueous solution
Synonym: MtTF1; TCF6; TCF6L1; TCF6L2; TCF6L3; mtTFA
Product Type: Chemical
Immunohistochemistry Immunoperoxidase of antibody to TFAM on formalin-fixed paraffin-embedded human small Intestine. [antibody concentration 3 μg/mL]
Immunofluorescence Immunofluorescence of antibody to TFAM on HeLa cell. [antibody concentration 10 μg/mL]
Western Blotting Western Blot analysis of TFAM expression in transfected 293T cell line by TFAM polyclonal antibody. Lanes Lane 1: TFAM transfected lysate (27.06 kDa). Lane 2: Non-transfected lysate.
Western Blotting TFAM polyclonal antibody. Western Blot analysis of TFAM expression in human kidney.
| antibody form | purified immunoglobulin |
| antibody product type | primary antibodies |
| biological source | mouse |
| clone | polyclonal |
| conjugate | unconjugated |
| form | buffered aqueous solution |
| NCBI accession no. | NM_003201.1   |
| Quality Level | 100 |
| shipped in | dry ice |
| species reactivity | human |
| storage temp. | −20°C |
| target post-translational modification | unmodified |
| technique(s) | direct immunofluorescence: suitable |
| immunohistochemistry (formalin-fixed, paraffin-embedded sections): suitable | |
| western blot: 1 μg/mL | |
| UniProt accession no. | Q00059 |
| Biochem/physiol Actions: | Transcription factor A, mitochondrial (TFAM) plays a vital role in transcription and replication of mammalian mitochondrial DNA (mtDNA). In addition, it is also implicated in mtDNA packaging. Polymorphism in the gene increases the risk of susceptibility to Alzheimer disease (AD). Additionally, mutation in the gene is associated with the development of mtDNA depletion syndrome. |
| Disclaimer: | Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals. |
| General description: | This gene encodes a mitochondrial transcription factor that is a key activator of mitochondrial transcription as well as a participant in mitochondrial genome replication. Studies in mice have demonstrated that this gene product is required to regulate the mitochondrial genome copy number and is essential for embryonic development. A mouse model for Kearns-Sayre syndrome was produced when expression of this gene was eliminated by targeted disruption in heart and muscle cells. (provided by RefSeq) |
| General description: | Transcription factor A, mitochondrial (TFAM) is encoded by the gene mapped to human chromosome 10q21.1. The gene codes for a DNA binding protein characterized with HMG (high mobility group)-box domains. |
| Immunogen: | TFAM (NP_003192.1, 1 a.a. ~ 246 a.a) full-length human protein. Sequence MAFLRSMWGVLSALGRSGAELCTGC |
| Physical form: | Solution in phosphate buffered saline, pH 7.4 |
| RIDADR | NONH for all modes of transport |
| Flash Point(F) | Not applicable |
| Flash Point(C) | Not applicable |
| Storage Temp. | −20°C |
| UNSPSC | 12352203 |