Anti-SLC40A1 antibody produced in rabbit
SIGMA/SAB1401666 - purified immunoglobulin, buffered aqueous solution
Synonym: FPN1; HFE4; IREG1; MST079; MSTP079; MTP1
Product Type: Chemical
Western Blotting SLC40A1 rabbit polyclonal antibody. Western Blot analysis of SLC40A1 expression in IMR-32.
Western Blotting SLC40A1 rabbit polyclonal antibody. Western Blot analysis of SLC40A1 expression in A-431.
Western Blotting SLC40A1 rabbit polyclonal antibody. Western Blot analysis of SLC40A1 expression in human liver.
Western Blotting Western Blot analysis of SLC40A1 expression in transfected 293T cell line by SLC40A1 polyclonal antibody. Lanes Lane 1: SLC40A1 transfected lysate (62.50 kDa). Lane 2: Non-transfected lysate.
| antibody form | purified immunoglobulin |
| antibody product type | primary antibodies |
| biological source | rabbit |
| clone | polyclonal |
| conjugate | unconjugated |
| form | buffered aqueous solution |
| NCBI accession no. | NM_014585.3   |
| Quality Level | 100 |
| shipped in | dry ice |
| species reactivity | human |
| storage temp. | −20°C |
| target post-translational modification | unmodified |
| technique(s) | western blot: 1 μg/mL |
| UniProt accession no. | Q9NP59 |
| Biochem/physiol Actions: | Ferroportin - 1 (FPN1) is an iron exporter protein that is involved in the transfer of iron from the external and internal sites into bloodstream and thus maintains iron homeostasis. FPN1 exports iron mostly from macrophages and enterocytes, also from hepatocytes. FPN1 is also known to transfer iron from placenta to the fetus. FPN1 is posttranslationally regulated by hepcidin and is ultimately degraded. Mutation in the gene results in the accumulation of iron in macrophages and intestine and subclinical anemia, leading to ferroportin disease. |
| Disclaimer: | Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals. |
| General description: | The protein encoded by this gene is a cell membrane protein that may be involved in iron export from duodenal epithelial cells. Defects in this gene are a cause of hemochromatosis type 4 (HFE4). (provided by RefSeq) |
| Immunogen: | SLC40A1 (NP_055400.1, 1 a.a. ~ 571 a.a) full-length human protein. Sequence MTRAGDHNRQRGCCGSLADYLTSAK |
| Physical form: | Solution in phosphate buffered saline, pH 7.4 |
| RIDADR | NONH for all modes of transport |
| Flash Point(F) | Not applicable |
| Flash Point(C) | Not applicable |
| Storage Temp. | −20°C |
| UNSPSC | 12352203 |