Anti-PNPLA3 antibody produced in rabbit
SIGMA/SAB1401851 - purified immunoglobulin, buffered aqueous solution
Synonym: ADPN; C22orf20; iPLA(2)epsilon
Product Type: Chemical
Western Blotting Western Blot analysis of PNPLA3 expression in transfected 293T cell line by PNPLA3 polyclonal antibody. Lanes Lane 1: PNPLA3 transfected lysate (52.80 kDa). Lane 2: Non-transfected lysate.
Western Blotting PNPLA3 rabbit polyclonal antibody. Western Blot analysis of PNPLA3 expression in mouse liver.
Western Blotting PNPLA3 rabbit polyclonal antibody. Western Blot analysis of PNPLA3 expression in human kidney.
| antibody form | purified immunoglobulin |
| antibody product type | primary antibodies |
| biological source | rabbit |
| clone | polyclonal |
| conjugate | unconjugated |
| form | buffered aqueous solution |
| NCBI accession no. | BC065195.1   |
| Quality Level | 100 |
| shipped in | dry ice |
| species reactivity | mouse, human |
| storage temp. | −20°C |
| target post-translational modification | unmodified |
| technique(s) | western blot: 1 μg/mL |
| UniProt accession no. | Q9NST1 |
| Application: | Anti-PNPLA3 antibody produced in rabbit has been used in western blotting. |
| Biochem/physiol Actions: | PNPLA3 (patatin like phospholipase domain containing 3) involves lipogenic transacetylase activity. Variation in PNPLA3 (patatin like phospholipase domain containing 3) is known to increase the fat content of hepatocytes, thereby promoting the severity of nonalcoholic liver disease. The gene is found to be associated with hepatic steatosis, liver fibrosis and cancer. PNPLA3 might be involved in energy homeostasis. PNPLA3 mediates triacylglycerol hydrolysis in adipocytes and is involved in the balance of energy usage cum storage in adipocytes. |
| Biochem/physiol Actions: | PNPLA3 mediates triacylglycerol hydrolysis in adipocytes and is involved in the balance of energy usage cum storage in adipocytes. |
| Disclaimer: | Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals. |
| General description: | Patatin like phospholipase domain containing 3 (PNPLA3) gene is mapped to human chromosome 22q13.3. The protein encoded by this gene is a triacylglycerol lipase. |
| Immunogen: | PNPLA3 (AAH65195.1, 1 a.a. ~ 481 a.a) full-length human protein. Sequence MYDAERGWSLSFAGCGFLGFYHVGA |
| Physical form: | Solution in phosphate buffered saline, pH 7.4 |
| RIDADR | NONH for all modes of transport |
| WGK Germany | WGK 1 |
| Flash Point(F) | Not applicable |
| Flash Point(C) | Not applicable |
| Storage Temp. | −20°C |
| UNSPSC | 12352203 |