Anti-WNT3A antibody produced in rabbit
SIGMA/SAB1401927 - purified immunoglobulin, buffered aqueous solution
Synonym: MGC119418; MGC119419; MGC119420
Product Type: Chemical
Western Blotting Western Blot analysis of WNT3A expression in transfected 293T cell line by WNT3A polyclonal antibody. Lanes Lane 1: WNT3A transfected lysate (42.90 kDa). Lane 2: Non-transfected lysate.
| antibody form | purified immunoglobulin |
| antibody product type | primary antibodies |
| biological source | rabbit |
| clone | polyclonal |
| conjugate | unconjugated |
| form | buffered aqueous solution |
| NCBI accession no. | BC103921   |
| Quality Level | 100 |
| shipped in | dry ice |
| species reactivity | human |
| storage temp. | −20°C |
| target post-translational modification | unmodified |
| technique(s) | western blot: 1 μg/mL |
| UniProt accession no. | P56704 |
| Biochem/physiol Actions: | During the differentiation of human neuronal progenitor cells, WNT3A (Wnt family member 3A) activates calmodulin dependent kinase II and increases free calcium in the cytosol via Wnt/Ca2+ signaling pathway. WNT3A is an oncogene and is upregulated in many types of cancer. WNT3A serves as a prognostic marker in diagnosing hepatocellular carcinoma. |
| Disclaimer: | Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals. |
| General description: | The WNT gene family consists of structurally related genes which encode secreted signaling proteins. These proteins have been implicated in oncogenesis and in several developmental processes, including regulation of cell fate and patterning during embryogenesis. This gene is a member of the WNT gene family. It encodes a protein which shows 96% amino acid identity to mouse Wnt3A protein, and 84% to human WNT3 protein, another WNT gene product. This gene is clustered with WNT14 gene, another family member, in chromosome 1q42 region. (provided by RefSeq) |
| Immunogen: | WNT3A (AAI03922.1, 1 a.a. ~ 385 a.a) full-length human protein. Sequence MAPLGYFLLLCSLKQALGSYPIWWS |
| Physical form: | Solution in phosphate buffered saline, pH 7.4 |
| RIDADR | NONH for all modes of transport |
| Flash Point(F) | Not applicable |
| Flash Point(C) | Not applicable |
| Storage Temp. | −20°C |
| UNSPSC | 12352203 |