Monoclonal Anti-MYLIP antibody produced in mouse
SIGMA/SAB1403211 - clone 3C10, purified immunoglobulin, buffered aqueous solution
Synonym: MIR
Product Type: Chemical
ELISA Detection limit for recombinant GST tagged MYLIP is 0.3 ng/mL as a capture antibody.
| antibody form | purified immunoglobulin |
| antibody product type | primary antibodies |
| biological source | mouse |
| clone | 3C10, monoclonal |
| conjugate | unconjugated |
| form | buffered aqueous solution |
| isotype | IgG2aκ |
| mol wt | antigen ~75.06 kDa |
| NCBI accession no. | BC002860   |
| Quality Level | 100 |
| shipped in | dry ice |
| species reactivity | human |
| storage temp. | −20°C |
| target post-translational modification | unmodified |
| technique(s) | capture ELISA: suitable |
| indirect ELISA: suitable | |
| UniProt accession no. | Q8WY64 |
| Biochem/physiol Actions: | Myosin regulatory light chain interacting protein (MYLIP) might have a role in cholesterol uptake. It modulates the levels of low density lipoprotein receptor by controlling the ubiquitination of the intracellular tail of the receptor and its lysosomal degradation. Overexpression of the protein in mice livers has been shown to cause hypercholesterolemia and atherosclerosis. |
| Disclaimer: | Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals. |
| General description: | Mouse monoclonal antibody raised against a full-length recombinant MYLIP. |
| General description: | Myosin regulatory light chain interacting protein (MYLIP) is an E3 ubiquitin ligase. The gene encoding it is localized on human chromosome 6p22.3. |
| Immunogen: | MYLIP (AAH02860, 1 a.a. ~ 445 a.a) full-length recombinant protein with GST tag. MW of the GST tag alone is 26 KDa. Sequence MLCYVTRPDAVLMEVEVEAKANGED |
| Physical form: | Solution in phosphate buffered saline, pH 7.4 |
| RIDADR | NONH for all modes of transport |
| WGK Germany | WGK 1 |
| Flash Point(F) | Not applicable |
| Flash Point(C) | Not applicable |
| Storage Temp. | −20°C |
| UNSPSC | 12352203 |