Monoclonal Anti-BMP7 antibody produced in mouse
SIGMA/SAB1403611 - clone S52, purified immunoglobulin, buffered aqueous solution
Synonym: OP-1
Product Type: Chemical
Western Blotting BMP7 monoclonal antibody, clone S52. Western Blot analysis of BMP7 expression in C32.
Western Blotting BMP7 monoclonal antibody, clone S52. Western Blot analysis of BMP7 expression in Raw 264.7.
Western Blotting BMP7 monoclonal antibody, clone S52. Western Blot analysis of BMP7 expression in A-549.
Western Blotting Western Blot analysis of BMP7 expression in transfected 293T cell line by BMP7 monoclonal antibody, clone S52. Lanes Lane 1: BMP7 transfected lysate (49.313 kDa). Lane 2: Non-transfected lysate.
Western Blotting BMP7 monoclonal antibody, clone S52. Western Blot analysis of BMP7 expression in human ovarian cancer.
Western Blotting QC Western Blot detection against Immunogen (73.15 kDa).
ELISA Detection limit for recombinant GST tagged BMP7 is 10 ng/mL as a capture antibody.
| antibody form | purified immunoglobulin |
| antibody product type | primary antibodies |
| biological source | mouse |
| clone | S52, monoclonal |
| conjugate | unconjugated |
| form | buffered aqueous solution |
| isotype | IgG1κ |
| mol wt | antigen ~73.52 kDa |
| NCBI accession no. | BC008584   |
| Quality Level | 100 |
| shipped in | dry ice |
| species reactivity | mouse, human |
| storage temp. | −20°C |
| target post-translational modification | unmodified |
| technique(s) | indirect ELISA: suitable |
| western blot: 1-5 μg/mL | |
| UniProt accession no. | P18075 |
| Biochem/physiol Actions: | As implied by their name, bone morphogenetic proteins (BMPs) promote and regulate bone development and growth. BMP-7 induces apoptosis in B-cells. It has a role in organ development and may have a role in liver regeneration. Mutations in the gene encoding the protein have been shown to affect the development of teeth, palate and other orofacial complexes. |
| Disclaimer: | Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals. |
| General description: | The bone morphogenetic proteins (BMPs) are a family of secreted signaling molecules that can induce ectopic bone growth. Many BMPs are part of the transforming growth factor-beta (TGFB) superfamily. BMPs were originally identified by an ability of demineralized bone extract to induce endochondral osteogenesis in vivo in an extraskeletal site. Based on its expression early in embryogenesis, the BMP encoded by this gene has a proposed role in early development and possible bone inductive activity. (provided by RefSeq) |
| Immunogen: | BMP7 (AAH08584, 1 a.a. ~ 431 a.a) full-length recombinant protein with GST tag. MW of the GST tag alone is 26 KDa. Sequence MHVRSLRAAAPHSFVALWAPLFLLR |
| Physical form: | Solution in phosphate buffered saline, pH 7.4 |
| RIDADR | NONH for all modes of transport |
| WGK Germany | WGK 1 |
| Flash Point(F) | Not applicable |
| Flash Point(C) | Not applicable |
| Storage Temp. | −20°C |
| UNSPSC | 12352203 |