Anti-CTBP2 antibody produced in mouse
SIGMA/SAB1405672 - purified immunoglobulin, buffered aqueous solution
Product Type: Chemical
Western Blotting Western Blot analysis of CTBP2 expression in transfected 293T cell line by CTBP2 polyclonal antibody. Lanes Lane 1: CTBP2 transfected lysate (56.43 kDa). Lane 2: Non-transfected lysate.
Western Blotting CTBP2 polyclonal antibody. Western Blot analysis of CTBP2 expression in HepG2.
Western Blotting CTBP2 polyclonal antibody. Western Blot analysis of CTBP2 expression in human pancreas.
| antibody form | purified immunoglobulin |
| antibody product type | primary antibodies |
| biological source | mouse |
| clone | polyclonal |
| conjugate | unconjugated |
| form | buffered aqueous solution |
| mol wt | antigen ~56.2 kDa |
| NCBI accession no. | BC037900   |
| Quality Level | 100 |
| shipped in | dry ice |
| species reactivity | human |
| storage temp. | −20°C |
| target post-translational modification | unmodified |
| technique(s) | western blot: 1 μg/mL |
| UniProt accession no. | P56545 |
| Biochem/physiol Actions: | The gene CTBP2 (C-terminal binding protein 2) encodes a protein that functions as a transcriptional co-repressor of several tumor suppressor genes resulting in enhanced cancer cell migration and invasion. Its expression is found to be upregulated in hepatocellular carcinoma (HCC). It may be a potential prognostic marker for post liver resection HCC. It is involved in several types of tumor initiation, progression and response to therapy. It is found to interact with the C-terminal region of adenovirus type 2/5 E1A protein, a region that negatively regulates tumorigenicity and the extent of oncogenic transformation. |
| General description: | This gene produces alternative transcripts encoding two distinct proteins. One protein is a transcriptional repressor, while the other isoform is a major component of specialized synapses known as synaptic ribbons. Both proteins contain a NAD+ binding domain similar to NAD+-dependent 2-hydroxyacid dehydrogenases. A portion of the 3′ untranslated region was used to map this gene to chromosome 21q21.3; however, it was noted that similar loci elsewhere in the genome are likely. Blast analysis shows that this gene is present on chromosome 10. (provided by RefSeq) |
| Immunogen: | CTBP2 (AAH37900.1, 1 a.a. ~ 513 a.a) full-length human protein. Sequence MRPGLPGPTGLCAQTSSRGQKSVLK |
| Physical form: | Solution in phosphate buffered saline, pH 7.4 |
| RIDADR | NONH for all modes of transport |
| WGK Germany | WGK 1 |
| Flash Point(F) | Not applicable |
| Flash Point(C) | Not applicable |
| Storage Temp. | −20°C |
| UNSPSC | 12352203 |